Nature Communications (Jul 2018)

Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish

  • Shaoyang Zhao,
  • Jianhong Xia,
  • Xiuhua Wu,
  • Leilei Zhang,
  • Pengtao Wang,
  • Haiyun Wang,
  • Heying Li,
  • Xiaoshan Wang,
  • Yan Chen,
  • Jean Agnetti,
  • Yinxiong Li,
  • Duanqing Pei,
  • Xiaodong Shu

DOI
https://doi.org/10.1038/s41467-018-05105-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

Read online

The functions of the class III PI3-kinase (PIK3C3) in gut homeostasis and innate immunity are poorly understood. Here the authors show that PIK3C3-deficient zebrafishes develop intestinal injury and inflammation due to mislocalization of cell junction proteins.