Nature Communications (Nov 2019)

HPV infection and the genital cytokine milieu in women at high risk of HIV acquisition

  • Lenine J. P. Liebenberg,
  • Lyle R. McKinnon,
  • Nonhlanhla Yende-Zuma,
  • Nigel Garrett,
  • Cheryl Baxter,
  • Ayesha B. M. Kharsany,
  • Derseree Archary,
  • Anne Rositch,
  • Natasha Samsunder,
  • Leila E. Mansoor,
  • Jo-Ann S. Passmore,
  • Salim S. Abdool Karim,
  • Quarraisha Abdool Karim

DOI
https://doi.org/10.1038/s41467-019-13089-2
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Cervicovaginal inflammation and human papillomavirus (HPV) are separately associated with increased risk of HIV acquisition. Here the authors longitudinally profile 48 cervicovaginal cytokines and HPV status in a large observational HIV high-risk cohort, and show the same cytokines associate with HPV infection and HIV risk.