ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration

Jie Wang; Cristina Zibetti; Peng Shang; Srinivasa R. Sripathi; Pingwu Zhang; Marisol Cano; Thanh Hoang; Shuli Xia; Hongkai Ji; Shannath L. Merbs; Donald J. Zack; James T. Handa; Debasish Sinha; Seth Blackshaw; Jiang Qian

doi:10.1038/s41467-018-03856-y

Nature Communications (Apr 2018)

ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration

Jie Wang,
Cristina Zibetti,
Peng Shang,
Srinivasa R. Sripathi,
Pingwu Zhang,
Marisol Cano,
Thanh Hoang,
Shuli Xia,
Hongkai Ji,
Shannath L. Merbs,
Donald J. Zack,
James T. Handa,
Debasish Sinha,
Seth Blackshaw,
Jiang Qian

Affiliations

Jie Wang: Department of Ophthalmology, Johns Hopkins University School of Medicine
Cristina Zibetti: Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine
Peng Shang: Department of Ophthalmology, Johns Hopkins University School of Medicine
Srinivasa R. Sripathi: Department of Ophthalmology, Johns Hopkins University School of Medicine
Pingwu Zhang: Department of Ophthalmology, Johns Hopkins University School of Medicine
Marisol Cano: Department of Ophthalmology, Johns Hopkins University School of Medicine
Thanh Hoang: Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine
Shuli Xia: Department of Neurology, Johns Hopkins University School of Medicine
Hongkai Ji: Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
Shannath L. Merbs: Department of Ophthalmology, Johns Hopkins University School of Medicine
Donald J. Zack: Department of Ophthalmology, Johns Hopkins University School of Medicine
James T. Handa: Department of Ophthalmology, Johns Hopkins University School of Medicine
Debasish Sinha: Department of Ophthalmology, Johns Hopkins University School of Medicine
Seth Blackshaw: Department of Ophthalmology, Johns Hopkins University School of Medicine
Jiang Qian: Department of Ophthalmology, Johns Hopkins University School of Medicine

DOI: https://doi.org/10.1038/s41467-018-03856-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Age-related macular degeneration (AMD) leads to dysfunctional retinal pigment epithelium (RPE) and vision loss. Here, the authors perform ATAC-seq to study chromatin accessibility and find that differentially accessible regions are enriched for photoreceptor and RPE-specific transcription factors in AMD

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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