Nature Communications (Aug 2019)

Divergent engagements between adeno-associated viruses with their cellular receptor AAVR

  • Ran Zhang,
  • Guangxue Xu,
  • Lin Cao,
  • Zixian Sun,
  • Yong He,
  • Mengtian Cui,
  • Yuna Sun,
  • Shentao Li,
  • Huapeng Li,
  • Lan Qin,
  • Mingxu Hu,
  • Zhengjia Yuan,
  • Zipei Rao,
  • Wei Ding,
  • Zihe Rao,
  • Zhiyong Lou

DOI
https://doi.org/10.1038/s41467-019-11668-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Multiple adeno-associated viruses (AAV) use the same receptor (AAVR), but the binding mode is not clear. Here, the authors determine the structures of the AAV1-AAVR and AAV5-AAVR complexes, identify residues necessary for virus entry and compare the receptor interfaces of different AAV capsids.