Optimization of nano-microparticle size and shape on wall-interaction: a human case study on an abdominal aortic aneurysm

Abstract

Spherical nano-microcarriers generally perform targeted delivery of drugs to blood vessels with lesions. Recently, some studies have shown the importance of the non-spherical nature of nano-microcarriers in their movement toward the target wall inside blood arteries. Non-spherical particles tend to collide and adhere to the target wall due to their high interaction level with the artery wall. However, detailed kinematic studies have yet to be carried out to optimize nano-microcarriers’ shape based on their delivery rate to the target wall inside the artery. In addition, it is important to note that the flow of fluid in vessels can have diverse patterns that may affect the movement of drug carriers having different shapes. It is therefore necessary to study the impact of fluid flow patterns on drug carriers, refine their shapes and sizes to achieve the desired drug delivery rate, and reduce the risk of toxicity in blood vessels that have disorders. In the present study, we tried to provide optimal delivery of different forms of nano-microcarriers to the abdominal aortic aneurysm (AAA) wall, which is a common and dangerous lesion in the artery, based on the rate of particle impact on the inner wall of the AAA and the rate of their exit from the downstream of the aorta artery. The results showed that the non-spherical shape strongly depends on the interaction of the particles on the inner wall of the AAA and their departure rate from the aorta artery. Different shapes with different shape factors have optimal delivery conditions compared to the size of each nano-microcarrier in the drug delivery aimed at the wall.

Keywords

• Drug delivery
• abdominal aortic aneurysm
• non-spherical particles
• wall-interaction