Creation and Assessment of Herbal Gel with Guava Leaf Extract

Abstract

Mouth ulcers, a common oral mucosal disorder, can cause discomfort and interfere with daily activities. Natural remedies like guava leaves extract have shown promising potential in managing such conditions due to their anti-inflammatory and antimicrobial properties. This study aimed to formulate and evaluate an aqueous gel of guava leaves extract for the treatment of mouth ulcers. The guava leaves extract was prepared using a maceration method and incorporated into a gelbase consisting of Carbopol 934P. Various formulations were prepared with different concentrations of guava leaves extract to optimize the formulation for maximum efficacy. The formulated gels were evaluated for their physicochemical properties, including pH, viscosity, spreadability, and drug content. The results indicated that the formulated aqueous gel exhibited desirable physicochemical properties, with optimal viscosity and spreadability for application on oral mucosa. The release studies demonstrated sustained release of active constituents from the gel matrix, ensuring prolonged therapeutic effect. Moreover, the optimized gel formulation showed significant antimicrobial activity against oral pathogens, suggesting its potential for managingmouth ulcers. In conclusion, the formulated aqueous gel of guava leaves extract holds promise as aneffective and natural treatment option for mouth ulcers.

Keywords

• mouth ulcers
• guava leaves extract
• aqueous gel
• formulation
• evaluation
• antimicrobial activity
• wound healing