Nature Communications (Jan 2023)
Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between the mTORC1 and CaSR-Gq signaling pathways
- Yulong Gong,
- Bingyuan Yang,
- Dingdong Zhang,
- Yue Zhang,
- Zihan Tang,
- Liu Yang,
- Katie C. Coate,
- Linlin Yin,
- Brittney A. Covington,
- Ravi S. Patel,
- Walter A. Siv,
- Katelyn Sellick,
- Matthew Shou,
- Wenhan Chang,
- E. Danielle Dean,
- Alvin C. Powers,
- Wenbiao Chen
Affiliations
- Yulong Gong
- Department of Molecular Physiology & Biophysics, Vanderbilt University
- Bingyuan Yang
- Department of Molecular Physiology & Biophysics, Vanderbilt University
- Dingdong Zhang
- Department of Molecular Physiology & Biophysics, Vanderbilt University
- Yue Zhang
- Department of Molecular Physiology & Biophysics, Vanderbilt University
- Zihan Tang
- Department of Molecular Physiology & Biophysics, Vanderbilt University
- Liu Yang
- Department of Molecular Physiology & Biophysics, Vanderbilt University
- Katie C. Coate
- Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center
- Linlin Yin
- Department of Molecular Physiology & Biophysics, Vanderbilt University
- Brittney A. Covington
- Department of Molecular Physiology & Biophysics, Vanderbilt University
- Ravi S. Patel
- Department of Molecular Physiology & Biophysics, Vanderbilt University
- Walter A. Siv
- Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center
- Katelyn Sellick
- Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center
- Matthew Shou
- Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center
- Wenhan Chang
- University of California San Francisco and San Francisco VA Medical Center
- E. Danielle Dean
- Department of Molecular Physiology & Biophysics, Vanderbilt University
- Alvin C. Powers
- Department of Molecular Physiology & Biophysics, Vanderbilt University
- Wenbiao Chen
- Department of Molecular Physiology & Biophysics, Vanderbilt University
- DOI
- https://doi.org/10.1038/s41467-022-35705-4
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 19
Abstract
Insufficient glucagon signalling results in hyperaminoacidemia, which drives adaptive proliferation of glucagon-producing α cells. Here the authors report that the amino acid sensitive calcium sensing receptor (CaSR) is necessary for α cell proliferation via Gq signalling during hyperaminoacidemia.
