An Efficient Procedure Based on a MW-Assisted Horner–Wadsworth-Emmons Reaction for the Synthesis of (Z)-3,3-Trisubstituted-a,b-unsaturated Esters

Abstract

A microwave-assisted HWE olefination process of readily accessible aryl-alkyl ketones has been developed to provide a rapid access to (Z)-3,3-trisubstituted-α,β-unsaturated methyl esters, key building blocks for the synthesis of biologically active compounds.

Keywords

• (Z)-3,3-trisubstituted α,β-unsaturated methyl esters
• aryl-alkyl ketones
• Horner–Wadsworth-Emmons reaction
• microwave-assisted reactions