Kidney haemodynamical disorders in abdominal hypertension rats

Abstract

Purpose: The aim of study is to analyze changes in renal blood circulation in abdominal hypertensive rats. Methods: Two groups of anesthetized male Wistar rats were examined: control group and group exposed to artificially elevated abdominal pressure. The later has been achieved by insufflations of air in abdominal cavity. X-ray angiographies of both groups were conducted after introduction of contrast medium. Results: The experiments have shown dramatic changes in time-related parameters of renal haemodynamics in abdominal hypertensive rats: appearance of contrast medium in kidney parenchyma before contrasting of heart and impaired synchrony in contrasting of kidneys Conclusions: Pneumoperitoneum upsets excretory function of kidneys, thus causing significant haemodynamical disorders. It could lead to further development of improper renal endocrinal and metabolic activity.

Keywords

• Abdominal hypertension
• renal haemodynamics
• angiography
• rat