A transcomplementing gene drive provides a flexible platform for laboratory investigation and potential field deployment

Víctor López Del Amo; Alena L. Bishop; Héctor M. Sánchez C.; Jared B. Bennett; Xuechun Feng; John M. Marshall; Ethan Bier; Valentino M. Gantz

doi:10.1038/s41467-019-13977-7

Nature Communications (Jan 2020)

A transcomplementing gene drive provides a flexible platform for laboratory investigation and potential field deployment

Víctor López Del Amo,
Alena L. Bishop,
Héctor M. Sánchez C.,
Jared B. Bennett,
Xuechun Feng,
John M. Marshall,
Ethan Bier,
Valentino M. Gantz

Affiliations

Víctor López Del Amo: Section of Cell and Developmental Biology, University of California San Diego
Alena L. Bishop: Section of Cell and Developmental Biology, University of California San Diego
Héctor M. Sánchez C.: Division of Epidemiology and Biostatistics, School of Public Health, University of California
Jared B. Bennett: Biophysics Graduate Group, University of California
Xuechun Feng: Section of Cell and Developmental Biology, University of California San Diego
John M. Marshall: Division of Epidemiology and Biostatistics, School of Public Health, University of California
Ethan Bier: Section of Cell and Developmental Biology, University of California San Diego
Valentino M. Gantz: Section of Cell and Developmental Biology, University of California San Diego

DOI: https://doi.org/10.1038/s41467-019-13977-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

Read online

Gene drives raise safety concerns around unintended propagation. Here the authors present a trans-complementing split-gene drive that requires inheritance of separate transgenes to assemble a fully functional drive.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal