Nature Communications (Jan 2022)
Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease
- Lucía Barbier-Torres,
- Ben Murray,
- Jin Won Yang,
- Jiaohong Wang,
- Michitaka Matsuda,
- Aaron Robinson,
- Aleksandra Binek,
- Wei Fan,
- David Fernández-Ramos,
- Fernando Lopitz-Otsoa,
- Maria Luque-Urbano,
- Oscar Millet,
- Nirmala Mavila,
- Hui Peng,
- Komal Ramani,
- Roberta Gottlieb,
- Zhaoli Sun,
- Suthat Liangpunsakul,
- Ekihiro Seki,
- Jennifer E. Van Eyk,
- Jose M. Mato,
- Shelly C. Lu
Affiliations
- Lucía Barbier-Torres
- Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center
- Ben Murray
- Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center
- Jin Won Yang
- Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center
- Jiaohong Wang
- Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center
- Michitaka Matsuda
- Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center
- Aaron Robinson
- Smidt Heart Institute, Cedars-Sinai Medical Center
- Aleksandra Binek
- Smidt Heart Institute, Cedars-Sinai Medical Center
- Wei Fan
- Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center
- David Fernández-Ramos
- Precision Medicine and Metabolism, CIC bioGUNE, BRTA, CIBERehd
- Fernando Lopitz-Otsoa
- Precision Medicine and Metabolism, CIC bioGUNE, BRTA, CIBERehd
- Maria Luque-Urbano
- Precision Medicine and Metabolism, CIC bioGUNE, BRTA, CIBERehd
- Oscar Millet
- Precision Medicine and Metabolism, CIC bioGUNE, BRTA, CIBERehd
- Nirmala Mavila
- Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center
- Hui Peng
- Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center
- Komal Ramani
- Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center
- Roberta Gottlieb
- Smidt Heart Institute, Cedars-Sinai Medical Center
- Zhaoli Sun
- Department of Surgery and Transplant Biology Research Center, Johns Hopkins University School of Medicine
- Suthat Liangpunsakul
- Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine
- Ekihiro Seki
- Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center
- Jennifer E. Van Eyk
- Smidt Heart Institute, Cedars-Sinai Medical Center
- Jose M. Mato
- Precision Medicine and Metabolism, CIC bioGUNE, BRTA, CIBERehd
- Shelly C. Lu
- Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center
- DOI
- https://doi.org/10.1038/s41467-022-28201-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Lower activity of MATα1, which catalyzes the synthesis of the methyl donor S-adenosylmethionine, and mitochondrial dysfunction occur in alcohol-associated liver disease (ALD). Here the authors report that the peptidyl-prolyl cis/trans isomerase PIN1 mediates a selective depletion of MATα1 in the mitochondria, which contributes to mitochondrial dysfunction and fat accumulation, in mouse models of ALD.
