Change in function of thl - and th2-lymphocytes and cytokine profile at chronic intoxication of ethanol

Abstract

It has been established during the experiments carried on noninbred rats that chronic intoxication of ethanol (30 days, total dose - 6,0 LD50) essentially reduces concentration of cytokines (IFNy, IL-2, IL-4, IL-6,IL-10) in blood, reduces interrelation of IFNy/IL-4 in comparison with the control, suppresses immune reactions, indicating the greater lesion of Th1-cells in comparison with Th2-lymphocytes

Keywords

• cytokines
• ethanol
• immunotoxycity
• Th1, Th2- lymphocytes