Synthesis of Enantiomeric Halolactones with Aromatic Ring, Their Anticancer Activity and Interactions with Biological Membranes

Witold Gładkowski; Aleksandra Pawlak; Aleksandra Włoch; Marcelina Mazur; Halina Kleszczyńska; Bożena Obmińska-Mrukowicz

doi:10.3390/proceedings2019022047

Proceedings (Aug 2019)

Synthesis of Enantiomeric Halolactones with Aromatic Ring, Their Anticancer Activity and Interactions with Biological Membranes

Witold Gładkowski,
Aleksandra Pawlak,
Aleksandra Włoch,
Marcelina Mazur,
Halina Kleszczyńska,
Bożena Obmińska-Mrukowicz

Affiliations

Witold Gładkowski: Department of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland
Aleksandra Pawlak: Department of Pharmacology and Toxicology, Wrocław University of Environmental and Life Sciences, Norwida 31, 50-375 Wrocław, Poland
Aleksandra Włoch: Department of Physics and Biophysics, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland
Marcelina Mazur: Department of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland
Halina Kleszczyńska: Department of Physics and Biophysics, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland
Bożena Obmińska-Mrukowicz: Department of Pharmacology and Toxicology, Wrocław University of Environmental and Life Sciences, Norwida 31, 50-375 Wrocław, Poland

DOI: https://doi.org/10.3390/proceedings2019022047
Journal volume & issue: Vol. 22, no. 1
p. 47

Abstract

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Studying the effect of chirality on the activity of tested compounds, we synthesized new series of the enantiomeric (ee = 98–100%) β-aryl-δ-halo-γ-lactones with defined configurations of stereogenic centers. [...]

lactones, enantiomers, lipase, antiproliferative activity, interactions with membranes

Published in Proceedings

ISSN: 2504-3900 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: General Works
Website: http://www.mdpi.com/journal/proceedings

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