Generation of induced pluripotent stem cell lines from a sister pair who suffered post-partum or recurrent Spontaneous Coronary Artery Dissections

Monique Bax; Keerat Junday; Siiri E Iismaa; Xenia Kaidonis; David Muller; Stephanie Hesselson; Robert M Graham

Stem Cell Research (Dec 2023)

Generation of induced pluripotent stem cell lines from a sister pair who suffered post-partum or recurrent Spontaneous Coronary Artery Dissections

Monique Bax,
Keerat Junday,
Siiri E Iismaa,
Xenia Kaidonis,
David Muller,
Stephanie Hesselson,
Robert M Graham

Affiliations

Monique Bax: Victor Chang Cardiac Research Institute, Darlinghurst 2010, Australia; University of New South Wales Sydney, Kensington, New South Wales 2052, Australia
Keerat Junday: Victor Chang Cardiac Research Institute, Darlinghurst 2010, Australia
Siiri E Iismaa: Victor Chang Cardiac Research Institute, Darlinghurst 2010, Australia; University of New South Wales Sydney, Kensington, New South Wales 2052, Australia
Xenia Kaidonis: Victor Chang Cardiac Research Institute, Darlinghurst 2010, Australia; University of New South Wales Sydney, Kensington, New South Wales 2052, Australia
David Muller: Victor Chang Cardiac Research Institute, Darlinghurst 2010, Australia; St Vincent’s Hospital, Darlinghurst, New South Wales 2010, Australia; University of New South Wales Sydney, Kensington, New South Wales 2052, Australia
Stephanie Hesselson: Victor Chang Cardiac Research Institute, Darlinghurst 2010, Australia
Robert M Graham: Victor Chang Cardiac Research Institute, Darlinghurst 2010, Australia; St Vincent’s Hospital, Darlinghurst, New South Wales 2010, Australia; University of New South Wales Sydney, Kensington, New South Wales 2052, Australia; Corresponding author at: Victor Chang Cardiac Research Institute, Darlinghurst 2010, Australia.

Journal volume & issue: Vol. 73
p. 103238

Abstract

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Spontaneous Coronary Artery Dissection (SCAD) results from a bleed within a coronary artery wall that impairs blood flow as it expands. It is the most common cause of myocardial infarction in pregnant women. Here, peripheral blood mononuclear cells from two sisters who had suffered SCADs were reprogrammed using Sendai Virus. Expression of pluripotency markers, capability to differentiate to the three germ layers, and cellular integrity were confirmed. This is the first report of a SCAD family induced pluripotent stem cell (iPSC) cohort, including a sister who suffered post-partum SCAD, and one who suffered from multiple recurrences.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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