MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling

Matthew Sermersheim; Adam D. Kenney; Pei-Hui Lin; Temet M. McMichael; Chuanxi Cai; Kristyn Gumpper; T. M. Ayodele Adesanya; Haichang Li; Xinyu Zhou; Ki-Ho Park; Jacob S. Yount; Jianjie Ma

doi:10.1038/s41467-020-17177-6

Nature Communications (Jul 2020)

MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling

Matthew Sermersheim,
Adam D. Kenney,
Pei-Hui Lin,
Temet M. McMichael,
Chuanxi Cai,
Kristyn Gumpper,
T. M. Ayodele Adesanya,
Haichang Li,
Xinyu Zhou,
Ki-Ho Park,
Jacob S. Yount,
Jianjie Ma

Affiliations

Matthew Sermersheim: Department of Surgery, The Ohio State University Wexner Medical Center
Adam D. Kenney: Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center
Pei-Hui Lin: Department of Surgery, The Ohio State University Wexner Medical Center
Temet M. McMichael: Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center
Chuanxi Cai: Department of Surgery, The Ohio State University Wexner Medical Center
Kristyn Gumpper: Department of Surgery, The Ohio State University Wexner Medical Center
T. M. Ayodele Adesanya: Department of Surgery, The Ohio State University Wexner Medical Center
Haichang Li: Department of Surgery, The Ohio State University Wexner Medical Center
Xinyu Zhou: Department of Surgery, The Ohio State University Wexner Medical Center
Ki-Ho Park: Department of Surgery, The Ohio State University Wexner Medical Center
Jacob S. Yount: Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center
Jianjie Ma: Department of Surgery, The Ohio State University Wexner Medical Center

DOI: https://doi.org/10.1038/s41467-020-17177-6
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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TRIM proteins are known to play critical roles in the context of viral infection. Here the authors establish MG53 (TRIM72) suppresses IFN and inflammation by modulation of ryanodine receptor related intracellular calcium induction.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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