CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells

Arnaud P. J. Giese; Yi-Quan Tang; Ghanshyam P. Sinha; Michael R. Bowl; Adam C. Goldring; Andrew Parker; Mary J. Freeman; Steve D. M. Brown; Saima Riazuddin; Robert Fettiplace; William R. Schafer; Gregory I. Frolenkov; Zubair M. Ahmed

doi:10.1038/s41467-017-00061-1

Nature Communications (Jun 2017)

CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells

Arnaud P. J. Giese,
Yi-Quan Tang,
Ghanshyam P. Sinha,
Michael R. Bowl,
Adam C. Goldring,
Andrew Parker,
Mary J. Freeman,
Steve D. M. Brown,
Saima Riazuddin,
Robert Fettiplace,
William R. Schafer,
Gregory I. Frolenkov,
Zubair M. Ahmed

Affiliations

Arnaud P. J. Giese: Department of Otorhinolaryngology Head & Neck Surgery, School of Medicine, University of Maryland
Yi-Quan Tang: Division of Neurobiology, MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus
Ghanshyam P. Sinha: Department of Physiology, College of Medicine, University of Kentucky
Michael R. Bowl: MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
Adam C. Goldring: Department of Neuroscience, School of Medicine, University of Wisconsin
Andrew Parker: MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
Mary J. Freeman: Department of Physiology, College of Medicine, University of Kentucky
Steve D. M. Brown: MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
Saima Riazuddin: Department of Otorhinolaryngology Head & Neck Surgery, School of Medicine, University of Maryland
Robert Fettiplace: Department of Neuroscience, School of Medicine, University of Wisconsin
William R. Schafer: Division of Neurobiology, MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus
Gregory I. Frolenkov: Department of Physiology, College of Medicine, University of Kentucky
Zubair M. Ahmed: Department of Otorhinolaryngology Head & Neck Surgery, School of Medicine, University of Maryland

DOI: https://doi.org/10.1038/s41467-017-00061-1
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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Inner ear hair cells detect sound through deflection of stereocilia that harbor mechanically-gated channels. Here the authors show that protein responsible for Usher syndrome, CIB2, interacts with these channels and is essential for their function and hearing in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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