Biologically Active Substances from Marine Hydrobionts with Antibacterial Activity in Composition of New Wound Dressings

Abstract

The data on the experimental study of the efficacy of the gel wound dressings based on chitosan and calcium alginate containing bioactive substances from marine hydrobionts with complex therapeutic action (sulfated polysaccharides from brown algae, hydrolyzed bivalves, peptides from nerve ganglia of cephalopods) are described. The model of thermal burns complicated by Staphylococcus aureus infection was used. Planimetric and bacteriological investigations revealed pronounced wound healing and antibacterial effects of the gel coating. The gel containing sulfated polysaccharides from brown algae showed the highest wound healing activity.

Keywords

• biologically active substances from marine hydrobionts
• chitosan
• alginate
• sulfated polysaccharides
• antibiotics
• staphylococcus
• thermal burn
• gel wound dressings