MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-β signalling in osteoblasts

Huan-Chang Zeng; Yangjin Bae; Brian C. Dawson; Yuqing Chen; Terry Bertin; Elda Munivez; Philippe M. Campeau; Jianning Tao; Rui Chen; Brendan H. Lee

doi:10.1038/ncomms15000

Nature Communications (Apr 2017)

MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-β signalling in osteoblasts

Huan-Chang Zeng,
Yangjin Bae,
Brian C. Dawson,
Yuqing Chen,
Terry Bertin,
Elda Munivez,
Philippe M. Campeau,
Jianning Tao,
Rui Chen,
Brendan H. Lee

Affiliations

Huan-Chang Zeng: Program in Developmental Biology, Baylor College of Medicine
Yangjin Bae: Department of Molecular and Human Genetics, Baylor College of Medicine
Brian C. Dawson: Department of Molecular and Human Genetics, Baylor College of Medicine
Yuqing Chen: Department of Molecular and Human Genetics, Baylor College of Medicine
Terry Bertin: Department of Molecular and Human Genetics, Baylor College of Medicine
Elda Munivez: Department of Molecular and Human Genetics, Baylor College of Medicine
Philippe M. Campeau: Department of Pediatrics, Sainte-Justine Hospital, University of Montreal
Jianning Tao: Department of Pediatrics, University of South Dakota School of Medicine
Rui Chen: Program in Developmental Biology, Baylor College of Medicine
Brendan H. Lee: Program in Developmental Biology, Baylor College of Medicine

DOI: https://doi.org/10.1038/ncomms15000
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 9

Abstract

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Control of osteocyte differentiation is not well understood. Here the authors show that the miR-23 cluster represses the TGF-β signalling repressor Prdm16 in osteoblasts, thus enhancing osteocyte differentiation and a low bone mass phenotype.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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