The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD

Chengzhang Fu; Asfandyar Sikandar; Jannik Donner; Nestor Zaburannyi; Jennifer Herrmann; Michael Reck; Irene Wagner-Döbler; Jesko Koehnke; Rolf Müller

doi:10.1038/s41467-017-01671-5

Nature Communications (Nov 2017)

The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD

Chengzhang Fu,
Asfandyar Sikandar,
Jannik Donner,
Nestor Zaburannyi,
Jennifer Herrmann,
Michael Reck,
Irene Wagner-Döbler,
Jesko Koehnke,
Rolf Müller

Affiliations

Chengzhang Fu: Department of Microbial Natural Products, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarland University, Campus E8.1
Asfandyar Sikandar: Helmholtz Institute for Pharmaceutical Research Saarland, Workgroup Structural Biology of Biosynthetic Enzymes, Helmholtz Centre for Infection Research, Saarland University, Campus E8.1
Jannik Donner: Helmholtz Center for Infection Research (HZI), Group Microbial Communication
Nestor Zaburannyi: Department of Microbial Natural Products, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarland University, Campus E8.1
Jennifer Herrmann: Department of Microbial Natural Products, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarland University, Campus E8.1
Michael Reck: Helmholtz Center for Infection Research (HZI), Group Microbial Communication
Irene Wagner-Döbler: Helmholtz Center for Infection Research (HZI), Group Microbial Communication
Jesko Koehnke: Helmholtz Institute for Pharmaceutical Research Saarland, Workgroup Structural Biology of Biosynthetic Enzymes, Helmholtz Centre for Infection Research, Saarland University, Campus E8.1
Rolf Müller: Department of Microbial Natural Products, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarland University, Campus E8.1

DOI: https://doi.org/10.1038/s41467-017-01671-5
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 9

Abstract

Read online

The mechanisms behind the antibacterial activity of the natural product carolacton are unknown. Here, the authors show that carolacton is a potent inhibitor of FolD/MTHFD enzymes (involved in folate-dependent C1 metabolism in bacteria and humans) and inhibits the growth of cancer cell lines

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal