Nature Communications (Mar 2021)
trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo
- Zachary D. Aron,
- Atousa Mehrani,
- Eric D. Hoffer,
- Kristie L. Connolly,
- Pooja Srinivas,
- Matthew C. Torhan,
- John N. Alumasa,
- Mynthia Cabrera,
- Divya Hosangadi,
- Jay S. Barbor,
- Steven C. Cardinale,
- Steven M. Kwasny,
- Lucas R. Morin,
- Michelle M. Butler,
- Timothy J. Opperman,
- Terry L. Bowlin,
- Ann Jerse,
- Scott M. Stagg,
- Christine M. Dunham,
- Kenneth C. Keiler
Affiliations
- Zachary D. Aron
- Microbiotix, Inc. One Innovation Dr.
- Atousa Mehrani
- Department of Chemistry and Biochemistry, Florida State University
- Eric D. Hoffer
- Department of Biochemistry and Emory Antibiotic Resistance Center, Emory University School of Medicine
- Kristie L. Connolly
- Department of Microbiology and Immunology, Uniformed Services University
- Pooja Srinivas
- Department of Biochemistry and Emory Antibiotic Resistance Center, Emory University School of Medicine
- Matthew C. Torhan
- Microbiotix, Inc. One Innovation Dr.
- John N. Alumasa
- Department of Biochemistry & Molecular Biology, Penn State University
- Mynthia Cabrera
- Department of Biochemistry & Molecular Biology, Penn State University
- Divya Hosangadi
- Department of Biochemistry & Molecular Biology, Penn State University
- Jay S. Barbor
- Microbiotix, Inc. One Innovation Dr.
- Steven C. Cardinale
- Microbiotix, Inc. One Innovation Dr.
- Steven M. Kwasny
- Microbiotix, Inc. One Innovation Dr.
- Lucas R. Morin
- Microbiotix, Inc. One Innovation Dr.
- Michelle M. Butler
- Microbiotix, Inc. One Innovation Dr.
- Timothy J. Opperman
- Microbiotix, Inc. One Innovation Dr.
- Terry L. Bowlin
- Microbiotix, Inc. One Innovation Dr.
- Ann Jerse
- Department of Microbiology and Immunology, Uniformed Services University
- Scott M. Stagg
- Department of Chemistry and Biochemistry, Florida State University
- Christine M. Dunham
- Department of Biochemistry and Emory Antibiotic Resistance Center, Emory University School of Medicine
- Kenneth C. Keiler
- Department of Biochemistry & Molecular Biology, Penn State University
- DOI
- https://doi.org/10.1038/s41467-021-22012-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Antibiotic-resistant bacterial pathogens pose a substantial threat to human health. Here, aided by structural analyses, the authors describe the molecular mechanism behind the activity of a series of compounds that inhibit trans-translation and are effective in eradicating N. gonorrhoeae infection in mice.
