Discovering human diabetes-risk gene function with genetics and physiological assays

Heshan Peiris; Sangbin Park; Shreya Louis; Xueying Gu; Jonathan Y. Lam; Olof Asplund; Gregory C. Ippolito; Rita Bottino; Leif Groop; Haley Tucker; Seung K. Kim

doi:10.1038/s41467-018-06249-3

Nature Communications (Sep 2018)

Discovering human diabetes-risk gene function with genetics and physiological assays

Heshan Peiris,
Sangbin Park,
Shreya Louis,
Xueying Gu,
Jonathan Y. Lam,
Olof Asplund,
Gregory C. Ippolito,
Rita Bottino,
Leif Groop,
Haley Tucker,
Seung K. Kim

Affiliations

Heshan Peiris: Department of Developmental Biology, Stanford University School of Medicine
Sangbin Park: Department of Developmental Biology, Stanford University School of Medicine
Shreya Louis: Department of Developmental Biology, Stanford University School of Medicine
Xueying Gu: Department of Developmental Biology, Stanford University School of Medicine
Jonathan Y. Lam: Department of Developmental Biology, Stanford University School of Medicine
Olof Asplund: Unit of Diabetes and Endocrinology, Lund University Diabetes Centre
Gregory C. Ippolito: Institute for Cellular and Molecular Biology and Department of Molecular Biosciences, University of Texas at Austin
Rita Bottino: Institute of Cellular Therapeutics, Allegheny Health Network
Leif Groop: Unit of Diabetes and Endocrinology, Lund University Diabetes Centre
Haley Tucker: Institute for Cellular and Molecular Biology and Department of Molecular Biosciences, University of Texas at Austin
Seung K. Kim: Department of Developmental Biology, Stanford University School of Medicine

DOI: https://doi.org/10.1038/s41467-018-06249-3
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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The function of genes linked to type 2 diabetes is poorly characterized. Here the authors combine Drosophila genetics and physiology with human islet biology to identify new regulators of insulin secretion including BCL11A.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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