Beilstein Journal of Organic Chemistry (Mar 2013)
Efficient synthesis of β’-amino-α,β-unsaturated ketones
Abstract
A general and simple procedure to access chiral β'-amino-α,β-enones, in seven steps, from an α,β unsaturated ester has been described. The use of a Horner–Wadsworth–Emmons reaction as a key step for generating the β'-amino-α,β-enones, permits access to a range of substrates under mild conditions and in moderate to high yield.
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