Efficient synthesis of β’-amino-α,β-unsaturated ketones

Abstract

A general and simple procedure to access chiral β'-amino-α,β-enones, in seven steps, from an α,β unsaturated ester has been described. The use of a Horner–Wadsworth–Emmons reaction as a key step for generating the β'-amino-α,β-enones, permits access to a range of substrates under mild conditions and in moderate to high yield.

Keywords

• β’-amino-α,β-unsaturated ketones
• Horner–Wadsworth–Emmons reaction
• stereoselective synthesis