Emergence of mcr-1 and mcr-3 variants coding for plasmid-mediated colistin resistance in Escherichia coli isolates from food- producing animals in South Korea

Kuastros Mekonnen Belaynehe; Seung Won Shin; Kyung Yoon Park; Ji Young Jang; Ho Geun Won; In Joong Yoon; Han Sang Yoo

International Journal of Infectious Diseases (Jul 2018)

Emergence of mcr-1 and mcr-3 variants coding for plasmid-mediated colistin resistance in Escherichia coli isolates from food- producing animals in South Korea

Kuastros Mekonnen Belaynehe,
Seung Won Shin,
Kyung Yoon Park,
Ji Young Jang,
Ho Geun Won,
In Joong Yoon,
Han Sang Yoo

Affiliations

Kuastros Mekonnen Belaynehe: Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea
Seung Won Shin: Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea
Kyung Yoon Park: Research Unit, Green Cross Veterinary Products, Yongin 17066, Republic of Korea
Ji Young Jang: Research Unit, Green Cross Veterinary Products, Yongin 17066, Republic of Korea
Ho Geun Won: Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea; Chung Ang Vaccine Laboratory, Daejeon 34055, Republic of Korea
In Joong Yoon: Chung Ang Vaccine Laboratory, Daejeon 34055, Republic of Korea
Han Sang Yoo: Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea; Institute of Green Bio Science and Technology, Seoul National University, Pyeongchang 25340, Republic of Korea; Corresponding author. Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea. Tel.: +82 2 880 1263; fax: +82 2 874 2738.

Journal volume & issue: Vol. 72
pp. 22 – 24

Abstract

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We hereby report the first characterization of mcr-3 gene from healthy animals in South Korea. Out of 636 E. coli isolates, collected between 2014- 2017, nine colistin resistant isolates were screened for the presence of mcr-1 and mcr-3 genes. Nine (1.4%) isolates had shown resistance for colistin and among them three and two isolates were mcr-1 harboring and mcr-3 harboring strains, respectively. All the colistin-resistant isolates were multidrug-resistant. mcr-1 and mcr-3 genes were confirmed to be transferred to a recipient E. coli J53 AZR. Keywords: mcr-3 gene, mcr-1 gene, Colistin resistance, Healthy animals, Transferability

Published in International Journal of Infectious Diseases

ISSN: 1201-9712 (Print); 1878-3511 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: http://www.journals.elsevier.com/international-journal-of-infectious-diseases/

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