Nature Communications (May 2022)
Long-term hepatitis B virus infection of rhesus macaques requires suppression of host immunity
- Sreya Biswas,
- Lauren N. Rust,
- Jochen M. Wettengel,
- Sofiya Yusova,
- Miranda Fischer,
- Julien N. Carson,
- Josie Johnson,
- Lei Wei,
- Trason Thode,
- Mohan R. Kaadige,
- Sunil Sharma,
- Majd Agbaria,
- Benjamin N. Bimber,
- Thomas Tu,
- Ulrike Protzer,
- Alexander Ploss,
- Jeremy V. Smedley,
- Gershon Golomb,
- Jonah B. Sacha,
- Benjamin J. Burwitz
Affiliations
- Sreya Biswas
- Vaccine & Gene Therapy Institute, Oregon Health & Science University
- Lauren N. Rust
- Vaccine & Gene Therapy Institute, Oregon Health & Science University
- Jochen M. Wettengel
- Vaccine & Gene Therapy Institute, Oregon Health & Science University
- Sofiya Yusova
- Vaccine & Gene Therapy Institute, Oregon Health & Science University
- Miranda Fischer
- Oregon National Primate Research Center, Oregon Health & Science University
- Julien N. Carson
- Vaccine & Gene Therapy Institute, Oregon Health & Science University
- Josie Johnson
- Oregon National Primate Research Center, Oregon Health & Science University
- Lei Wei
- Department of Molecular Biology, Princeton University
- Trason Thode
- Translational Genomics Research Institute
- Mohan R. Kaadige
- Translational Genomics Research Institute
- Sunil Sharma
- Translational Genomics Research Institute
- Majd Agbaria
- Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem
- Benjamin N. Bimber
- Oregon National Primate Research Center, Oregon Health & Science University
- Thomas Tu
- Storr Liver Centre, Westmead Clinical School and Westmead Institute for Medical Research, Faculty of Medicine and Health, The University of Sydney
- Ulrike Protzer
- Institute of Virology, Technical University of Munich / Helmholtz Zentrum München
- Alexander Ploss
- Department of Molecular Biology, Princeton University
- Jeremy V. Smedley
- Oregon National Primate Research Center, Oregon Health & Science University
- Gershon Golomb
- Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem
- Jonah B. Sacha
- Vaccine & Gene Therapy Institute, Oregon Health & Science University
- Benjamin J. Burwitz
- Vaccine & Gene Therapy Institute, Oregon Health & Science University
- DOI
- https://doi.org/10.1038/s41467-022-30593-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Here, Biswas et al. present and characterize a second-generation model of HBV infection in rhesus macaques, showing that extended infection requires suppression of host immunity.
