Case Reports in Oncology (Sep 2020)

Other Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders, Diffuse Large B-Cell Lymphoma Type, in a Patient with Behçet’s Disease Treated with Cyclosporine A

  • Yuka Urano,
  • Rintaro Ohe,
  • Akane Yamada,
  • Takanobu Kabasawa,
  • Kazushi Suzuki,
  • Takumi Kitaoka,
  • Nobuyuki Tamazawa,
  • Naing Ye Aung,
  • Aya Utsunomiya,
  • Tomomi Toubai,
  • Kenichi Ishizawa

DOI
https://doi.org/10.1159/000510362
Journal volume & issue
Vol. 13, no. 3
pp. 1145 – 1151

Abstract

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A 40-year-old man had been treated for Behçet’s disease (BD) with cyclosporine A (CsA) for 14 years. He presented multiple lymphadenopathies with fever. Histological examination of surgical biopsy showed other iatrogenic immunodeficiency-associated lymphoproliferative disorders, diffuse large B-cell lymphoma type with positivity for Epstein-Barr virus encoding RNA-1 (EBER-1). BCL2-IgH, BCL6-IgH, and MYC-IgH translocations were not detected. CsA was stopped, and R-CHOP therapy was initiated. However, his lymphoma was chemotherapy resistant and rapidly progressed. To the best of our knowledge, this is the first case of diffuse large B-cell lymphoma that occurred in a BD patient treated with CsA reported in English. Both BD and CsA are associated with the pathogenesis of lymphoma. We also describe extremely rare cases in the form of a literature review.

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