Research of serum total and high-molecular-weight adiponectin levels in patients with type 2 diabetic retinopathy

Abstract

AIM:To explore the levels of serum total adiponectin, high-molecular-weight(HMW)adiponectin and its ratio in type 2 diabetic retinopathy and to investigate risk factors of non-proliferative diabetic retinopathy.METHODS:Three hundred and seventy-four subjects were recruited from an epidemiological survey, including 88 patients with proliferative diabetic retinopathy, 124 patients with non-proliferative diabetic retinopathy, 78 patients only with type 2 diabetes mellitus and 84 healthy volunteers. Demographics, physical and laboratory parameters were collected. Serum total and HMW adiponectin levels were detected by ELISA. The main statistical analysis included covariance analysis and cumulative logit model.RESULTS:Total adiponectin level was higher in healthy group than in groups of only diabetes, non-proliferative and proliferative diabetic retinopathy(harmonic mean, 5.717, 3.310, 3.288, 3.822 μg/ml, F=18.792, PPF=14.025, PP>0.05). The ratio of HMW adiponectin and total adiponectin had no differences among four groups(F=0.650, P>0.05). Drug history, high levels of high density lipoprotein cholesterol, total and HMW adiponectin had protective effects to the non-proliferative diabetic retinopathy(PCONCLUSION:The lower concentrations of serum total and HMW adiponectin may result in the occurrence of non-proliferative diabetic retinopathy. And the total adiponectin level was related to the severity of diabetic retinopathy.

Keywords

• adiponectin
• high-molecular-weight adiponectin
• diabetic retinopathy