Chronic medical conditions and risk of sepsis.

Abstract

BackgroundWe sought to determine the associations between baseline chronic medical conditions and future risk of sepsis.MethodsLongitudinal cohort study using the 30,239 community-dwelling participants of the REGARDS cohort. We determined associations between baseline chronic medical conditions and incident sepsis episodes, defined as hospitalization for an infection with the presence of infection plus two or more systemic inflammatory response syndrome criteria.ResultsOver the mean observation time of 4.6 years (February 5, 2003 through October 14, 2011), there were 975 incident cases of sepsis. Incident sepsis episodes were associated with older age (pConclusionsIndividuals with chronic medical conditions are at increased risk of future sepsis events.