Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion

Deniz A. Madencioglu; Karina Kruth; Mallory Shin; Nancy Andreasen; Thomas Wassink; Aislinn Williams

Stem Cell Research (Mar 2022)

Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion

Deniz A. Madencioglu,
Karina Kruth,
Mallory Shin,
Nancy Andreasen,
Thomas Wassink,
Aislinn Williams

Affiliations

Deniz A. Madencioglu: Department of Psychiatry, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA
Karina Kruth: Department of Psychiatry, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA
Mallory Shin: Department of Pathology, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA
Nancy Andreasen: Department of Psychiatry, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA
Thomas Wassink: Department of Psychiatry, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA
Aislinn Williams: Department of Psychiatry, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA; Corresponding author.

Journal volume & issue: Vol. 59
p. 102636

Abstract

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16p11.2 copy number variations have been associated with neurodevelopmental disorders. Human induced pluripotent stem cells were generated from fibroblasts obtained from a patient diagnosed with schizophrenia with a 16p11.2 deletion. The generated cell line was further validated for its pluripotency and potential to differentiate into the three germ layers.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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