mBio (Feb 2021)
SARS-CoV-2 Genomic Variation in Space and Time in Hospitalized Patients in Philadelphia
- John Everett,
- Pascha Hokama,
- Aoife M. Roche,
- Shantan Reddy,
- Young Hwang,
- Lyanna Kessler,
- Abigail Glascock,
- Yize Li,
- Jillian N. Whelan,
- Susan R. Weiss,
- Scott Sherrill-Mix,
- Kevin McCormick,
- Samantha A. Whiteside,
- Jevon Graham-Wooten,
- Layla A. Khatib,
- Ayannah S. Fitzgerald,
- Ronald G. Collman,
- Frederic Bushman
Affiliations
- John Everett
- Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Pascha Hokama
- Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Aoife M. Roche
- Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Shantan Reddy
- Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Young Hwang
- Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Lyanna Kessler
- Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Abigail Glascock
- Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Yize Li
- Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Jillian N. Whelan
- Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Susan R. Weiss
- Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Scott Sherrill-Mix
- Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Kevin McCormick
- Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Samantha A. Whiteside
- Pulmonary, Allergy and Critical Care Division, Department of Medicine; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
- Jevon Graham-Wooten
- Pulmonary, Allergy and Critical Care Division, Department of Medicine; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
- Layla A. Khatib
- Pulmonary, Allergy and Critical Care Division, Department of Medicine; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
- Ayannah S. Fitzgerald
- Pulmonary, Allergy and Critical Care Division, Department of Medicine; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
- Ronald G. Collman
- ORCiD
- Pulmonary, Allergy and Critical Care Division, Department of Medicine; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
- Frederic Bushman
- Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- DOI
- https://doi.org/10.1128/mBio.03456-20
- Journal volume & issue
-
Vol. 12,
no. 1
Abstract
Understanding how SARS-CoV-2 spreads globally and within infected individuals is critical to the development of mitigation strategies. We found that most lineages in Philadelphia had resembled sequences from New York, suggesting infection primarily but not exclusively from this location.
