Nature Communications (Feb 2017)
The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma
- Weiwei Zhai,
- Tony Kiat-Hon Lim,
- Tong Zhang,
- Su-Ting Phang,
- Zenia Tiang,
- Peiyong Guan,
- Ming-Hwee Ng,
- Jia Qi Lim,
- Fei Yao,
- Zheng Li,
- Poh Yong Ng,
- Jie Yan,
- Brian K. Goh,
- Alexander Yaw-Fui Chung,
- Su-Pin Choo,
- Chiea Chuen Khor,
- Wendy Wei-Jia Soon,
- Ken Wing-Kin Sung,
- Roger Sik-Yin Foo,
- Pierce Kah-Hoe Chow
Affiliations
- Weiwei Zhai
- Department of Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research
- Tony Kiat-Hon Lim
- Department of Pathology, Singapore General Hospital
- Tong Zhang
- Department of Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research
- Su-Ting Phang
- Division of Surgical Oncology, National Cancer Centre
- Zenia Tiang
- Department of Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research
- Peiyong Guan
- Department of Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research
- Ming-Hwee Ng
- Department of Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research
- Jia Qi Lim
- Department of Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research
- Fei Yao
- Department of Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research
- Zheng Li
- Department of Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research
- Poh Yong Ng
- Department of Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research
- Jie Yan
- Department of Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research
- Brian K. Goh
- Department of Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital
- Alexander Yaw-Fui Chung
- Department of Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital
- Su-Pin Choo
- Division of Medical Oncology, National Cancer Centre
- Chiea Chuen Khor
- Department of Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research
- Wendy Wei-Jia Soon
- Department of Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research
- Ken Wing-Kin Sung
- Department of Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research
- Roger Sik-Yin Foo
- Department of Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research
- Pierce Kah-Hoe Chow
- Division of Surgical Oncology, National Cancer Centre
- DOI
- https://doi.org/10.1038/ncomms14565
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 9
Abstract
Hepatocellular carcinoma has one of the poorest survival rates amongst cancers. Here, the authors highlight the intra-tumour heterogeneity of this disease, finding that spatially closer tumour sectors are genetically more similar and that intra-hepatic metastasis is accompanied by rapid genetic diversification.
