Diagnostic significance of the determination of peripheral blood lymphocytes for predicting the onset of pregnancy in patients with repeated implant failures in groups with different protocols of the assisted reproductive technology program

Abstract

Purpose of the study. Study of the diagnostic significance of the determination of peripheral blood lymphocytes with phenotypes significantly different from the control values for predicting the onset of pregnancy in groups with different protocols of the assisted reproductive technology program in patients with repeated implant failures. Material and methods. The study included 70 patients with repeated failures of implantation in the in vitro fertilisation program: 33 patients in a protocol with a gonadotropin-releasing hormone antagonist (antHNRH), 37 patients in a cryocycle. Results of the study. Patients in the stimulated cycle showed a high diagnostic significance of the definition of a subpopulation of lymphocytes related to congenital immunity (CD3+CD8+, CD56+), and in patients in the cryotype, on the one hand subpopulation of lymphocytes related to adaptive immunity (CD3+), and on the other CD8+, which includes subpopulations of lymphocytes and congenital, and adaptive immunity. The conclusion. High specificity of these tests allows to identify patients with the prospect of pregnancy.

Keywords

• cd56+
• cd3-cd8+
• cd8+
• cd3+
• repeated failures of implantation
• cd56 +
• cd3-cd8+
• cd8+
• cd3+
• diagnostic significance
• specificity
• sensitivity