Severe Bordetella pertussis infection and vaccine issue in Chongqing, from 2012 to 2018

Zhidai Liu; Shan Liu; Yi Shu; Zuqun Yang; Bin Peng; Hongmei Xu; Qubei Li; Zhengxiu Luo; Jihong Dai; Enmei Liu; Zhou Fu; Lin Zou

International Journal of Infectious Diseases (Jul 2019)

Severe Bordetella pertussis infection and vaccine issue in Chongqing, from 2012 to 2018

Zhidai Liu,
Shan Liu,
Yi Shu,
Zuqun Yang,
Bin Peng,
Hongmei Xu,
Qubei Li,
Zhengxiu Luo,
Jihong Dai,
Enmei Liu,
Zhou Fu,
Lin Zou

Affiliations

Zhidai Liu: Center for Clinical Molecular Medicine, Children’s Hospital of Chongqing Medical University, Yuzhong District, Chongqing, China; Ministry of Education Key Laboratory of Development and Disorders, Children’s Hospital, Chongqing Medical University, Yuzhong District, Chongqing, China; Key Laboratory of Pediatrics in Chongqing, Children’s Hospital, Chongqing Medical University, Chongqing, China
Shan Liu: Center for Clinical Molecular Medicine, Children’s Hospital of Chongqing Medical University, Yuzhong District, Chongqing, China; Ministry of Education Key Laboratory of Development and Disorders, Children’s Hospital, Chongqing Medical University, Yuzhong District, Chongqing, China; Key Laboratory of Pediatrics in Chongqing, Children’s Hospital, Chongqing Medical University, Chongqing, China
Yi Shu: Center for Clinical Molecular Medicine, Children’s Hospital of Chongqing Medical University, Yuzhong District, Chongqing, China; Ministry of Education Key Laboratory of Development and Disorders, Children’s Hospital, Chongqing Medical University, Yuzhong District, Chongqing, China; Key Laboratory of Pediatrics in Chongqing, Children’s Hospital, Chongqing Medical University, Chongqing, China
Zuqun Yang: Ministry of Education Key Laboratory of Development and Disorders, Children’s Hospital, Chongqing Medical University, Yuzhong District, Chongqing, China; Key Laboratory of Pediatrics in Chongqing, Children’s Hospital, Chongqing Medical University, Chongqing, China; Department of Preventive Medicine, Children’s Hospital, Chongqing Medical University, Yuzhong District, Chongqing, China
Bin Peng: Department of Health Statistics, School of Public Health, Chongqing Medical University, Yuzhong District, Chongqing, China
Hongmei Xu: Department of Infectious Disease, Children’s Hospital, Chongqing Medical University, Yuzhong District, Chongqing, China; Ministry of Education Key Laboratory of Development and Disorders, Children’s Hospital, Chongqing Medical University, Yuzhong District, Chongqing, China; Key Laboratory of Pediatrics in Chongqing, Children’s Hospital, Chongqing Medical University, Chongqing, China
Qubei Li: Department of Respiratory Medicine, Children’s Hospital, Chongqing Medical University, Yuzhong District, Chongqing, China; Ministry of Education Key Laboratory of Development and Disorders, Children’s Hospital, Chongqing Medical University, Yuzhong District, Chongqing, China; Key Laboratory of Pediatrics in Chongqing, Children’s Hospital, Chongqing Medical University, Chongqing, China
Zhengxiu Luo: Department of Respiratory Medicine, Children’s Hospital, Chongqing Medical University, Yuzhong District, Chongqing, China; Ministry of Education Key Laboratory of Development and Disorders, Children’s Hospital, Chongqing Medical University, Yuzhong District, Chongqing, China; Key Laboratory of Pediatrics in Chongqing, Children’s Hospital, Chongqing Medical University, Chongqing, China
Jihong Dai: Department of Respiratory Medicine, Children’s Hospital, Chongqing Medical University, Yuzhong District, Chongqing, China; Ministry of Education Key Laboratory of Development and Disorders, Children’s Hospital, Chongqing Medical University, Yuzhong District, Chongqing, China; Key Laboratory of Pediatrics in Chongqing, Children’s Hospital, Chongqing Medical University, Chongqing, China
Enmei Liu: Department of Respiratory Medicine, Children’s Hospital, Chongqing Medical University, Yuzhong District, Chongqing, China; Ministry of Education Key Laboratory of Development and Disorders, Children’s Hospital, Chongqing Medical University, Yuzhong District, Chongqing, China; Key Laboratory of Pediatrics in Chongqing, Children’s Hospital, Chongqing Medical University, Chongqing, China
Zhou Fu: Department of Respiratory Medicine, Children’s Hospital, Chongqing Medical University, Yuzhong District, Chongqing, China; Ministry of Education Key Laboratory of Development and Disorders, Children’s Hospital, Chongqing Medical University, Yuzhong District, Chongqing, China; Key Laboratory of Pediatrics in Chongqing, Children’s Hospital, Chongqing Medical University, Chongqing, China
Lin Zou: Center for Clinical Molecular Medicine, Children’s Hospital of Chongqing Medical University, Yuzhong District, Chongqing, China; Ministry of Education Key Laboratory of Development and Disorders, Children’s Hospital, Chongqing Medical University, Yuzhong District, Chongqing, China; Key Laboratory of Pediatrics in Chongqing, Children’s Hospital, Chongqing Medical University, Chongqing, China; Corresponding author at: Center for Clinical Molecular Medicine, Children’s Hospital, Chongqing Medical University, 136 Zhongshan Er Road, Yuzhong District, Chongqing 400014, China.

Journal volume & issue: Vol. 84
pp. 102 – 108

Abstract

Read online

Objective: Pertussis is a highly contagious respiratory illness mainly caused by the Gram-negative bacterium Bordetella pertussis. The infection of B. pertussis has been increasing and the current diagnosis of pertussis in children is challenging; little is known of B. pertussis infection in Chongqing. Methods: There were 25,441 children (14,863 male and 10,578 female) with suspected pertussis enrolled in our retrospective study from December 2012 to November 2018. Then 800 children with suspected B. pertussis infection were randomly chosen to be evaluated by simultaneous amplification and testing in this prospective study. Results: Infants younger than 12 months had the greatest burden of pertussis, and the incidence of pertussis in Chongqing appeared to have a periodic pattern. The problem of vaccine quality in China was more serious than previously reported based on the fluctuation of infection rates from 2012 to 2018. Simultaneous amplification and testing to detect B. pertussis RNA (Area Under Curve: 0.900 and Kappa value: 0.831) had better diagnostic performance than real-time PCR for B. pertussis DNA (Area Under Curve: 0.869 and Kappa value: 0.690). Conclusions: We revealed the characteristics of B. pertussis infection and vaccine issues in Chongqing. Simultaneous amplification and testing could be a potential novel assay for measuring B. pertussis infection in the future. Keywords: Pertussis, Epidemiology, Vaccine, Simultaneous amplification and testing

Published in International Journal of Infectious Diseases

ISSN: 1201-9712 (Print); 1878-3511 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: http://www.journals.elsevier.com/international-journal-of-infectious-diseases/

About the journal