IMMUNOLOGICAL INDEXES AND CYTOKINE PROFILE IN THE CHILDREN DURING INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS

Abstract

Abstract. Sixty-nine children (5 to 14 years old) with infectious mononucleosis caused by EBV were observed in acute phase and during recovery period. The indexes under study did evaluate cell-mediated and humoral immunity, levels of spontaneous and mitogen-induced production of IL-2, IL-10, IFNγ by peripheral blood mononuclears. We have founded appropriate changes to be dependent on clinical phase of the disease. The most significant changes were revealed during acute phase of disease. A positive dynamics of cell-mediated and humoral immune response was observed during convalescence period. However, complete normalization of most immunologic indexes and cytokine status did not occur, corresponding to the clinical signs. This situation necessitates immune rehabilitation to be carried out for the children having at this phase of infectious mononucleosis.

Keywords

• immunity
• cytokines
• infectious mononucleosis
• il-2
• il-10
• ifnγ