Nature Communications (Apr 2020)
The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC
- Robert Verity,
- Ozkan Aydemir,
- Nicholas F. Brazeau,
- Oliver J. Watson,
- Nicholas J. Hathaway,
- Melchior Kashamuka Mwandagalirwa,
- Patrick W. Marsh,
- Kyaw Thwai,
- Travis Fulton,
- Madeline Denton,
- Andrew P. Morgan,
- Jonathan B. Parr,
- Patrick K. Tumwebaze,
- Melissa Conrad,
- Philip J. Rosenthal,
- Deus S. Ishengoma,
- Jeremiah Ngondi,
- Julie Gutman,
- Modest Mulenga,
- Douglas E. Norris,
- William J. Moss,
- Benedicta A. Mensah,
- James L. Myers-Hansen,
- Anita Ghansah,
- Antoinette K. Tshefu,
- Azra C. Ghani,
- Steven R. Meshnick,
- Jeffrey A. Bailey,
- Jonathan J. Juliano
Affiliations
- Robert Verity
- Medical Research Council Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London
- Ozkan Aydemir
- Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University
- Nicholas F. Brazeau
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Oliver J. Watson
- Medical Research Council Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London
- Nicholas J. Hathaway
- Program in Bioinformatics and Integrative Biology, University of Massachusetts
- Melchior Kashamuka Mwandagalirwa
- Kinshasa School of Public Health, Hôpital Général Provincial de Référence de Kinshasa
- Patrick W. Marsh
- Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University
- Kyaw Thwai
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Travis Fulton
- Division of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill
- Madeline Denton
- Division of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill
- Andrew P. Morgan
- Division of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill
- Jonathan B. Parr
- Division of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill
- Patrick K. Tumwebaze
- Infectious Disease Research Collaboration
- Melissa Conrad
- Department of Medicine, University of California- San Francisco
- Philip J. Rosenthal
- Department of Medicine, University of California- San Francisco
- Deus S. Ishengoma
- National Institute for Medical Research
- Jeremiah Ngondi
- RTI International
- Julie Gutman
- Malaria Branch, Center for Global Health, Centers for Disease Control
- Modest Mulenga
- Tropical Disease Research Centre
- Douglas E. Norris
- Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health
- William J. Moss
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- Benedicta A. Mensah
- Noguchi Memorial Institute of Medical Research, University of Ghana
- James L. Myers-Hansen
- Noguchi Memorial Institute of Medical Research, University of Ghana
- Anita Ghansah
- Noguchi Memorial Institute of Medical Research, University of Ghana
- Antoinette K. Tshefu
- Kinshasa School of Public Health, Hôpital Général Provincial de Référence de Kinshasa
- Azra C. Ghani
- Medical Research Council Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London
- Steven R. Meshnick
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Jeffrey A. Bailey
- Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University
- Jonathan J. Juliano
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- DOI
- https://doi.org/10.1038/s41467-020-15779-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 10
Abstract
The genome of the malaria parasite Plasmodium falciparum contains a record of past evolutionary forces. Here, using 2537 parasite sequences from the Democratic Republic of the Congo, the authors demonstrate how drug pressure and human movement have shaped the present-day parasite population.
