Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension

Shin Watanabe; Kiyotake Ishikawa; Maria Plataki; Olympia Bikou; Erik Kohlbrenner; Jaume Aguero; Lahouaria Hadri; Iratxe Zarragoikoetxea; Kenneth Fish; Jane A. Leopold; Roger J. Hajjar

doi:10.1177/2045894018799738

Pulmonary Circulation (Sep 2018)

Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension

Shin Watanabe,
Kiyotake Ishikawa,
Maria Plataki,
Olympia Bikou,
Erik Kohlbrenner,
Jaume Aguero,
Lahouaria Hadri,
Iratxe Zarragoikoetxea,
Kenneth Fish,
Jane A. Leopold,
Roger J. Hajjar

Affiliations

Shin Watanabe: Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Kiyotake Ishikawa: Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Maria Plataki: Weill Cornell Medicine, Pulmonary & Critical Care Medicine, New York, NY, USA
Olympia Bikou: Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Erik Kohlbrenner: Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Jaume Aguero: Hospital Universitari i Politecnic La Fe, Valencia, Spain
Lahouaria Hadri: Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Iratxe Zarragoikoetxea: Hospital Universitari i Politecnic La Fe, Valencia, Spain
Kenneth Fish: Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Jane A. Leopold: Cardiovascular Medicine Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
Roger J. Hajjar: Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA

DOI: https://doi.org/10.1177/2045894018799738
Journal volume & issue: Vol. 8

Abstract

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Nebulization delivery of adeno-associated virus serotype 1 encoding sarcoplasmic reticulum Ca 2+ -ATPase2a (AAV1.SERCA2a) gene was examined in a Yukatan miniature swine model of chronic pulmonary hypertension (n = 13). Nebulization of AAV1.SERCA2a resulted in homogenous distribution of vectors, lower pulmonary vascular resistance, and a trend towards better long-term survival compared to control animals.

Published in Pulmonary Circulation

ISSN: 2045-8940 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system; Medicine: Internal medicine: Specialties of internal medicine: Diseases of the respiratory system
Website: https://onlinelibrary.wiley.com/journal/20458940

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