Evaluation of the Diagnostic Value of the Cluster of Differentiation 10 in the Diagnosis of Follicular Thyroid Carcinoma

Abstract

Objectives: Few studies have so far focused on the role of the cluster of differentiation 10 (CD10) in the prognosis of papillary thyroid carcinoma in Iran. Accordingly, this study aimed at evaluating the diagnostic value of CD10 in follicular thyroid carcinoma. Materials and Methods: This cross-sectional study was performed on 89 patients with thyroid carcinoma at Imam Reza Hospital (Tabriz Medical Sciences) during 2016-2017. The diagnostic value of the CD10 test was evaluated for the accurate diagnosis of papillary thyroid carcinoma. Finally, data were analyzed using Mann-Whitney, chi-square, and Pearson correlation tests. Results: Among the studied samples by the CD10 method, it was found that 41 (46.06%) and 48 (53.94%) were positive and negative, respectively. There was a significant correlation between CD10 expression and tumor size (P=0.0001), as well as lymph node involvement (P=0.031) and capsular invasion (P=0.008). Conclusions: In general, the CD10 biomarker could be an accessory diagnostic tool in addition to basic methods in the diagnosis of the follicular variant of papillary carcinoma although its diagnostic value in follicular carcinoma is not sufficiently high.

Keywords

• follicular adenocarcinoma
• papillary carcinoma
• cd10