Prevalence and risk factors of tigecycline-induced liver injury: A multicenter retrospective study

Abstract

ABSTRACT: Objective: We conducted this multicenter retrospective study to evaluate the prevalence, clinical patterns, and risk factors for tigecycline-induced liver injury, which is a type of drug-induced liver injury (DILI). Methods: Inpatients receiving intravenous tigecycline for ≥7 days were included. Patient information was collected to assess possible DILIs. The pattern and severity of tigecycline DILI were evaluated. A multivariable logistic regression model was used to identify the independent risk factors associated with tigecycline DILI. Results: A total of 986 patients were identified and 397 patients were included in this study. The prevalence of tigecycline DILI was 10.3% (95% confidence interval [CI] = 7.51–13.7%). The most common type of tigecycline DILI was cholestatic, with mild severity observed in most cases. Abnormal baseline alanine aminotransferase levels (odds ratio [OR] = 3.11, 95% CI = 1.55–6.24, P = 0.001), intensive care unit admission (OR = 2.63, 95% CI = 1.32–5.36, P = 0.006), and treatment length (in weeks) (OR = 1.25, 95% CI = 1.05–1.49, P = 0.011) were independent risk factors for tigecycline DILI. Conclusion: Our results indicate that the prevalence of tigecycline DILI is high, and that the patients at risk should receive special attention.

Keywords

• tigecycline
• drug-induced liver injury
• prevalence
• cholestatic
• alanine aminotransferase