Nature Communications (Jan 2020)
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis
- Maria Escala-Garcia,
- Jean Abraham,
- Irene L. Andrulis,
- Hoda Anton-Culver,
- Volker Arndt,
- Alan Ashworth,
- Paul L. Auer,
- Päivi Auvinen,
- Matthias W. Beckmann,
- Jonathan Beesley,
- Sabine Behrens,
- Javier Benitez,
- Marina Bermisheva,
- Carl Blomqvist,
- William Blot,
- Natalia V. Bogdanova,
- Stig E. Bojesen,
- Manjeet K. Bolla,
- Anne-Lise Børresen-Dale,
- Hiltrud Brauch,
- Hermann Brenner,
- Sara Y. Brucker,
- Barbara Burwinkel,
- Carlos Caldas,
- Federico Canzian,
- Jenny Chang-Claude,
- Stephen J. Chanock,
- Suet-Feung Chin,
- Christine L. Clarke,
- Fergus J. Couch,
- Angela Cox,
- Simon S. Cross,
- Kamila Czene,
- Mary B. Daly,
- Joe Dennis,
- Peter Devilee,
- Janet A. Dunn,
- Alison M. Dunning,
- Miriam Dwek,
- Helena M. Earl,
- Diana M. Eccles,
- A. Heather Eliassen,
- Carolina Ellberg,
- D. Gareth Evans,
- Peter A. Fasching,
- Jonine Figueroa,
- Henrik Flyger,
- Manuela Gago-Dominguez,
- Susan M. Gapstur,
- Montserrat García-Closas,
- José A. García-Sáenz,
- Mia M. Gaudet,
- Angela George,
- Graham G. Giles,
- David E. Goldgar,
- Anna González-Neira,
- Mervi Grip,
- Pascal Guénel,
- Qi Guo,
- Christopher A. Haiman,
- Niclas Håkansson,
- Ute Hamann,
- Patricia A. Harrington,
- Louise Hiller,
- Maartje J. Hooning,
- John L. Hopper,
- Anthony Howell,
- Chiun-Sheng Huang,
- Guanmengqian Huang,
- David J. Hunter,
- Anna Jakubowska,
- Esther M. John,
- Rudolf Kaaks,
- Pooja Middha Kapoor,
- Renske Keeman,
- Cari M. Kitahara,
- Linetta B. Koppert,
- Peter Kraft,
- Vessela N. Kristensen,
- Diether Lambrechts,
- Loic Le Marchand,
- Flavio Lejbkowicz,
- Annika Lindblom,
- Jan Lubiński,
- Arto Mannermaa,
- Mehdi Manoochehri,
- Siranoush Manoukian,
- Sara Margolin,
- Maria Elena Martinez,
- Tabea Maurer,
- Dimitrios Mavroudis,
- Alfons Meindl,
- Roger L. Milne,
- Anna Marie Mulligan,
- Susan L. Neuhausen,
- Heli Nevanlinna,
- William G. Newman,
- Andrew F. Olshan,
- Janet E. Olson,
- Håkan Olsson,
- Nick Orr,
- Paolo Peterlongo,
- Christos Petridis,
- Ross L. Prentice,
- Nadege Presneau,
- Kevin Punie,
- Dhanya Ramachandran,
- Gad Rennert,
- Atocha Romero,
- Mythily Sachchithananthan,
- Emmanouil Saloustros,
- Elinor J. Sawyer,
- Rita K. Schmutzler,
- Lukas Schwentner,
- Christopher Scott,
- Jacques Simard,
- Christof Sohn,
- Melissa C. Southey,
- Anthony J. Swerdlow,
- Rulla M. Tamimi,
- William J. Tapper,
- Manuel R. Teixeira,
- Mary Beth Terry,
- Heather Thorne,
- Rob A. E. M. Tollenaar,
- Ian Tomlinson,
- Melissa A. Troester,
- Thérèse Truong,
- Clare Turnbull,
- Celine M. Vachon,
- Lizet E. van der Kolk,
- Qin Wang,
- Robert Winqvist,
- Alicja Wolk,
- Xiaohong R. Yang,
- Argyrios Ziogas,
- Paul D. P. Pharoah,
- Per Hall,
- Lodewyk F. A. Wessels,
- Georgia Chenevix-Trench,
- Gary D. Bader,
- Thilo Dörk,
- Douglas F. Easton,
- Sander Canisius,
- Marjanka K. Schmidt
Affiliations
- Maria Escala-Garcia
- Division of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital
- Jean Abraham
- Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Irene L. Andrulis
- Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital
- Hoda Anton-Culver
- Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine
- Volker Arndt
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Alan Ashworth
- UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
- Paul L. Auer
- Cancer Prevention Program, Fred Hutchinson Cancer Research Center
- Päivi Auvinen
- Cancer Center, Kuopio University Hospital
- Matthias W. Beckmann
- Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg
- Jonathan Beesley
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- Sabine Behrens
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Javier Benitez
- Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO)
- Marina Bermisheva
- Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences
- Carl Blomqvist
- Department of Oncology, Helsinki University Hospital, University of Helsinki
- William Blot
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
- Natalia V. Bogdanova
- Department of Radiation Oncology, Hannover Medical School
- Stig E. Bojesen
- Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital
- Manjeet K. Bolla
- Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Anne-Lise Børresen-Dale
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet
- Hiltrud Brauch
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
- Hermann Brenner
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Sara Y. Brucker
- Department of Gynecology and Obstetrics, University of Tübingen
- Barbara Burwinkel
- Molecular Epidemiology Group, C080, German Cancer Research Center (DKFZ)
- Carlos Caldas
- Cancer Research UK Cambridge Institute, Department of Oncology, Li Ka Shing Centre, University of Cambridge
- Federico Canzian
- Genomic Epidemiology Group, German Cancer Research Center (DKFZ)
- Jenny Chang-Claude
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Stephen J. Chanock
- Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health
- Suet-Feung Chin
- Cancer Research UK Cambridge Institute, University of Cambridge
- Christine L. Clarke
- Westmead Institute for Medical Research, University of Sydney
- Fergus J. Couch
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Angela Cox
- Department of Oncology and Metabolism, Sheffield Institute for Nucleic Acids (SInFoNiA), University of Sheffield
- Simon S. Cross
- Academic Unit of Pathology, Department of Neuroscience, University of Sheffield
- Kamila Czene
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Mary B. Daly
- Department of Clinical Genetics, Fox Chase Cancer Center
- Joe Dennis
- Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Peter Devilee
- Department of Pathology, Leiden University Medical Center
- Janet A. Dunn
- Warwick Clinical Trials Unit, University of Warwick
- Alison M. Dunning
- Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Miriam Dwek
- Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster
- Helena M. Earl
- Cambridge Breast Unit and NIHR Cambridge Biomedical Research Centre, University of Cambridge NHS Foundation Hospitals
- Diana M. Eccles
- Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton
- A. Heather Eliassen
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Carolina Ellberg
- Department of Cancer Epidemiology, Clinical Sciences, Lund University
- D. Gareth Evans
- Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester
- Peter A. Fasching
- Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg
- Jonine Figueroa
- Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health
- Henrik Flyger
- Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital
- Manuela Gago-Dominguez
- Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS
- Susan M. Gapstur
- Epidemiology Research Program, American Cancer Society
- Montserrat García-Closas
- Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health
- José A. García-Sáenz
- Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC)
- Mia M. Gaudet
- Epidemiology Research Program, American Cancer Society
- Angela George
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Graham G. Giles
- Cancer Epidemiology Division, Cancer Council Victoria
- David E. Goldgar
- Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine
- Anna González-Neira
- Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO)
- Mervi Grip
- Department of Surgery, Oulu University Hospital, University of Oulu
- Pascal Guénel
- Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), University Paris-Saclay, INSERM, University Paris-Sud
- Qi Guo
- Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Christopher A. Haiman
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California
- Niclas Håkansson
- Institute of Environmental Medicine, Karolinska Institutet
- Ute Hamann
- Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
- Patricia A. Harrington
- Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Louise Hiller
- Warwick Clinical Trials Unit, University of Warwick
- Maartje J. Hooning
- Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute
- John L. Hopper
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
- Anthony Howell
- Division of Cancer Sciences, University of Manchester
- Chiun-Sheng Huang
- Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine
- Guanmengqian Huang
- Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
- David J. Hunter
- Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Anna Jakubowska
- Department of Genetics and Pathology, Pomeranian Medical University
- Esther M. John
- Division of Oncology, Department of Medicine, Stanford Cancer Institute, Stanford University School of Medicine
- Rudolf Kaaks
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Pooja Middha Kapoor
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Renske Keeman
- Division of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital
- Cari M. Kitahara
- Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Linetta B. Koppert
- Department of Surgical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute
- Peter Kraft
- Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Vessela N. Kristensen
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet
- Diether Lambrechts
- VIB, VIB Center for Cancer Biology
- Loic Le Marchand
- Epidemiology Program, University of Hawaii Cancer Center
- Flavio Lejbkowicz
- Carmel Medical Center and Technion Faculty of Medicine, Clalit National Cancer Control Center
- Annika Lindblom
- Department of Molecular Medicine and Surgery, Karolinska Institutet
- Jan Lubiński
- Department of Genetics and Pathology, Pomeranian Medical University
- Arto Mannermaa
- Translational Cancer Research Area, University of Eastern Finland
- Mehdi Manoochehri
- Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
- Siranoush Manoukian
- Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano (INT)
- Sara Margolin
- Department of Oncology, Sšdersjukhuset
- Maria Elena Martinez
- Moores Cancer Center, University of California San Diego
- Tabea Maurer
- Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf
- Dimitrios Mavroudis
- Department of Medical Oncology, University Hospital of Heraklion
- Alfons Meindl
- Department of Gynecology and Obstetrics, Ludwig Maximilian University of Munich
- Roger L. Milne
- Cancer Epidemiology Division, Cancer Council Victoria
- Anna Marie Mulligan
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Susan L. Neuhausen
- Department of Population Sciences, Beckman Research Institute of City of Hope
- Heli Nevanlinna
- Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki
- William G. Newman
- Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester
- Andrew F. Olshan
- Department of Epidemiology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Janet E. Olson
- Department of Health Sciences Research, Mayo Clinic
- Håkan Olsson
- Department of Cancer Epidemiology, Clinical Sciences, Lund University
- Nick Orr
- Centre for Cancer Research and Cell Biology, Queen’s University Belfast
- Paolo Peterlongo
- Genome Diagnostics Program, IFOM - the FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology
- Christos Petridis
- Research Oncology, Guy’s Hospital, King’s College London
- Ross L. Prentice
- Cancer Prevention Program, Fred Hutchinson Cancer Research Center
- Nadege Presneau
- Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster
- Kevin Punie
- Department of Oncology, Leuven Multidisciplinary Breast Center, Leuven Cancer Institute, University Hospitals Leuven
- Dhanya Ramachandran
- Gynaecology Research Unit, Hannover Medical School
- Gad Rennert
- Carmel Medical Center and Technion Faculty of Medicine, Clalit National Cancer Control Center
- Atocha Romero
- Medical Oncology Department, Hospital Universitario Puerta de Hierro
- Mythily Sachchithananthan
- Westmead Institute for Medical Research, University of Sydney
- Emmanouil Saloustros
- Department of Oncology, University Hospital of Larissa
- Elinor J. Sawyer
- Research Oncology, Guy’s Hospital, King’s College London
- Rita K. Schmutzler
- Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne
- Lukas Schwentner
- Department of Gynaecology and Obstetrics, University Hospital Ulm
- Christopher Scott
- Department of Health Sciences Research, Mayo Clinic
- Jacques Simard
- Genomics Center, Research Center, Centre Hospitalier Universitaire de Québec - Université Laval
- Christof Sohn
- National Center for Tumor Diseases, University of Heidelberg
- Melissa C. Southey
- Precision Medicine, School of Clinical Sciences at Monash Health, Monash University
- Anthony J. Swerdlow
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Rulla M. Tamimi
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- William J. Tapper
- Faculty of Medicine, University of Southampton
- Manuel R. Teixeira
- Department of Genetics, Portuguese Oncology Institute
- Mary Beth Terry
- Department of Epidemiology, Mailman School of Public Health, Columbia University
- Heather Thorne
- Peter MacCallum Cancer Center
- Rob A. E. M. Tollenaar
- Department of Surgery, Leiden University Medical Center
- Ian Tomlinson
- Institute of Cancer and Genomic Sciences, University of Birmingham
- Melissa A. Troester
- Department of Epidemiology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Thérèse Truong
- Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), University Paris-Saclay, INSERM, University Paris-Sud
- Clare Turnbull
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Celine M. Vachon
- Department of Health Sciences Research, Mayo Clinic
- Lizet E. van der Kolk
- Family Cancer Clinic, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital
- Qin Wang
- Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Robert Winqvist
- Biocenter Oulu, Cancer and Translational Medicine Research Unit, Laboratory of Cancer Genetics and Tumor Biology, University of Oulu
- Alicja Wolk
- Institute of Environmental Medicine, Karolinska Institutet
- Xiaohong R. Yang
- Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health
- Argyrios Ziogas
- Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine
- Paul D. P. Pharoah
- Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Per Hall
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Lodewyk F. A. Wessels
- Division of Molecular Carcinogenesis, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital
- Georgia Chenevix-Trench
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- Gary D. Bader
- Department of Molecular Genetics, University of Toronto
- Thilo Dörk
- Gynaecology Research Unit, Hannover Medical School
- Douglas F. Easton
- Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Sander Canisius
- Division of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital
- Marjanka K. Schmidt
- Division of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital
- DOI
- https://doi.org/10.1038/s41467-019-14100-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
In breast cancer the contribution of different genetic variants to disease heritability is complex and not fully understood. Here, the authors present a network-based analysis in 84,567 patients studying ~7.3 million variants, identifying gene modules associated with breast cancer survival.
