Dataset on safety and protective efficacy studies of COVID-19 vaccine candidates based on structurally modified plant virus in female hamsters

A.O. Kovalenko; E.M. Ryabchevskaya; E.A. Evtushenko; O.A. Kondakova; P.A. Ivanov; M.V. Arkhipenko; N.A. Nikitin; O.V. Karpova

Data in Brief (Jun 2023)

Dataset on safety and protective efficacy studies of COVID-19 vaccine candidates based on structurally modified plant virus in female hamsters

A.O. Kovalenko,
E.M. Ryabchevskaya,
E.A. Evtushenko,
O.A. Kondakova,
P.A. Ivanov,
M.V. Arkhipenko,
N.A. Nikitin,
O.V. Karpova

Affiliations

A.O. Kovalenko: Corresponding author.; Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow 119234, Russian Federation
E.M. Ryabchevskaya: Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow 119234, Russian Federation
E.A. Evtushenko: Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow 119234, Russian Federation
O.A. Kondakova: Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow 119234, Russian Federation
P.A. Ivanov: Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow 119234, Russian Federation
M.V. Arkhipenko: Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow 119234, Russian Federation
N.A. Nikitin: Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow 119234, Russian Federation
O.V. Karpova: Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow 119234, Russian Federation

Journal volume & issue: Vol. 48
p. 109158

Abstract

Read online

This data article is related to the previous research, which addressed the development of a COVID-19 recombinant vaccine candidate. Here, we present the additional data in support of the safety and protective efficacy evaluation of two COVID-19 vaccine candidates based on the coronaviruses’ S protein fragments and a structurally modified plant virus – spherical particles. The effectiveness of the experimental vaccines was studied against the SARS-CoV-2 virus in an in vivo infection model in female Syrian hamsters. The body weight of vaccinated laboratory animals was monitored. The histological assessment data of the infected with the SARS-CoV-2 virus hamsters’ lungs are provided.

Published in Data in Brief

ISSN: 2352-3409 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Science: Science (General)
Website: http://www.journals.elsevier.com/data-in-brief/

About the journal

Abstract

Keywords