精准医学杂志 (Dec 2023)
RISK FACTORS FOR SHORT-TERM MAJOR ADVERSE CARDIOVASCULAR EVENTS FOLLOWING PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION WITH TYPE 2 DIABETES MELLITUS
Abstract
Objective To investigate risk factors for short-term major adverse cardiovascular events (MACE) following percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) with type 2 diabetes mellitus (T2DM). Methods We retrospectively analyzed the clinical data of 147 patients with AMI with T2DM who underwent PCI in Kaifeng people’s Hospital from August 2016 to January 2020 as well as their information on MACE within 3 months after PCI. The patients were divided into MACE group and normal group according to whether MACE occurred or not within 3 months after operation. The two groups were compared in terms of blood glucose variability [standard deviation of blood glucose (SDBG), mean amplitude of glycemic excursions (MAGE), absolute mean of daily differences (MODD), and postprandial glucose excursions (PPGE)] within 72 h after operation as well as total cholesterol (TC), high-sensitivity C-reactive protein (hs-CRP), and left ventricular ejection fraction (LVEF) after operation. The risk factors for the occurrence of MACE were analyzed. Results The incidence of MACE within 3 months after PCI was 23.81%. The MACE group showed significantly higher levels of SDBG, MAGE, MODD, and PPGE within 72 h after operation and a significantly higher hs-CRP level after operation (t=10.206-24.388,P<0.05) and a significantly lower LVEF after operation (t=8.711,P<0.05) compared with the normal group. And postoperative MAGE ≥4.50 mmol/L, PPGE ≥3.50 mmol/L, hs-CRP ≥10 mg/L, and LVEF <50% were independent risk factors for the short-term occurrence of MACE after PCI in patients with AMI with T2DM (OR=3.927-7.501,P<0.05). Conclusion There is a higher possibility of MACE within 3 months after PCI for AMI in patients with T2DM with increased glycemic variability parameters after operation. Increased glycemic variability parameters within 72 h after operation and increased hs-CRP levels and decreased LVEF after operation are risk factors for short-term MACE following PCI in patients with AMI with T2DM, which should be paid attention to.
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