Communications Biology (Jul 2022)

Core cysteine residues in the Plasminogen-Apple-Nematode (PAN) domain are critical for HGF/c-MET signaling

  • Debjani Pal,
  • Kuntal De,
  • Carly M. Shanks,
  • Kai Feng,
  • Timothy B. Yates,
  • Jennifer Morrell-Falvey,
  • Russell B. Davidson,
  • Jerry M. Parks,
  • Wellington Muchero

DOI
https://doi.org/10.1038/s42003-022-03582-8
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 12

Abstract

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Core cysteine residues in the Plasminogen-Apple-Nematode (PAN) domain are essential for HGF/c-MET signaling and regulate their interaction, perinuclear localization, and cellular internalization. Thus, targeting PAN may represent a mechanism for the selective regulation of the c-MET pathway, with relevance to cancer treatment.