Hyperbaric Oxygenation, Antihypoxant and Antioxidative Therapy for Acute Myocardial Infarction

Abstract

The paper contains information on the currently available methods for intensive care for acute myocardial infarction (AMI), by using hyperbaric oxygenation (HBO), antihypoxants, and antioxidants. The presented information is based on the data available in the literature and on the results of the authors’ own studies made in 428 patients with AMI, in whom the time course of changes was determined in blood gas and in the biochemical parameters characterizing energy metabolism and free radical lipid peroxidation. Along with the conventional treatment (thrombolysis, restriction of a necrotic area, myocardial hemodynamic unloading, Labori mixture, anticoagulants, disaggregants, etc.), multimodality therapy for AMI used HBO sessions and antioxidants. The studies have provided evidence that it is possible and expedient to effectively and safely use HBO in AMI. Criteria for selecting the patients to undergo HBO, the time of its use, the choice of barotherapy regimes, and the nature of concomitant therapy are given. The application of the currently available methods for intensive care for hypoxia in AMI (HBO in combination with antihypoxants and antioxidants) can reduce the length of stay at hospital and in resuscitative and intensive care units and considerably decrease mortality rates.