Nature Communications (Apr 2020)
Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity
- Ji A Seo,
- Min-Cheol Kang,
- Won-Mo Yang,
- Won Min Hwang,
- Sang Soo Kim,
- Soo Hyun Hong,
- Jee-In Heo,
- Achana Vijyakumar,
- Leandro Pereira de Moura,
- Aykut Uner,
- Hu Huang,
- Seung Hwan Lee,
- Inês S. Lima,
- Kyong Soo Park,
- Min Seon Kim,
- Yossi Dagon,
- Thomas E. Willnow,
- Vanita Aroda,
- Theodore P. Ciaraldi,
- Robert R. Henry,
- Young-Bum Kim
Affiliations
- Ji A Seo
- Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School
- Min-Cheol Kang
- Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School
- Won-Mo Yang
- Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School
- Won Min Hwang
- Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School
- Sang Soo Kim
- Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School
- Soo Hyun Hong
- Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School
- Jee-In Heo
- Division of Endocrinology, Department of Internal Medicine, Korea University College of Medicine
- Achana Vijyakumar
- Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School
- Leandro Pereira de Moura
- Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School
- Aykut Uner
- Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School
- Hu Huang
- Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School
- Seung Hwan Lee
- Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School
- Inês S. Lima
- Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School
- Kyong Soo Park
- Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University
- Min Seon Kim
- Department of Internal Medicine, Asan Medical Center, University of Ulsan, College of Medicine
- Yossi Dagon
- Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School
- Thomas E. Willnow
- Molecular Cardiovascular Research, Max-Delbrueck-Center for Molecular Medicine
- Vanita Aroda
- Veterans Affairs San Diego Healthcare System (9111 G)
- Theodore P. Ciaraldi
- Veterans Affairs San Diego Healthcare System (9111 G)
- Robert R. Henry
- Veterans Affairs San Diego Healthcare System (9111 G)
- Young-Bum Kim
- Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-020-15963-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Hepatokines are proteins secreted by the liver that can regulate whole body metabolism. Here the authors identify apolipoprotein J as a hepatokine that regulates muscle glucose metabolism and insulin resistance through a low-density lipoprotein receptor-related protein−2 mediated mechanism in mice.
