Effectiveness of probiotic therapy in chronic purulent maxillary sinusitis in patients with type 1 diabetes mellitus

Abstract

Background. The problem of chronic purulent maxillary sinusitis (CPMS) in patients with type 1 diabetes mellitus (T1DM) is relevant due to the increased risk of infections, complicated course of the disease, impact on quality of life, frequency of relapses, economic burden and the need for a multidisciplinary approach to treatment. Exploring new therapies, such as probiotics, may improve treatment efficacy and quality of life in patients with T1DM. The purpose of the work was to study the effectiveness of probiotic therapy in the comprehensive treatment of patients with CPMS and concomitant T1DM. Materials and methods. Patients with CPMS were under our supervision, some of them had concomitant decompensated T1DM. A number of patients received a standard course of therapy with a multiprobiotic, others — without a probiotic. In some cases, the exacerbation of CPMS was not accompanied by other pathologies. All patients underwent an otolaryngological examination and assessment of the intestinal microbiome before and after treatment. Integral hematological coefficients and spectrophotometric determinations of middle mass molecules were used. Results. In patients with CPMS and T1DM, dysbiosis of the large intestine and endogenous intoxication were observed, which is associated with a decrease in the general resistance of the body. Probiotic therapy in case of CPMS in patients with T1DM has a number of potential advantages, since this type of diabetes complicates the course of many diseases due to weakened immunity and increased susceptibility to infections. Chronic sinusitis in patients with T1DM can be particularly difficult, and conventional treatments do not always provide the desired results. The practical significance of the obtained results is that in order to achieve the maximum effect of probiotic therapy for a certain nosology, it is important to choose probiotics containing specific strains of bacteria that have proven their effectiveness in clinical studies. Conclusions. The results of treatment with a multiprobiotic showed significant effectiveness: a decrease in the level of endogenous intoxication, stimulation of factors of non-specific resistance and influence on conditionally pathogenic microflora.

Keywords

• sinusitis
• probiotic
• diabetes mellitus
• colon microbiome
• hematological indices
• middle mass molecules