Regulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling

Wenji Piao; Yanbao Xiong; Konrad Famulski; C. Colin Brinkman; Lushen Li; Nicholas Toney; Chelsea Wagner; Vikas Saxena; Thomas Simon; Jonathan S. Bromberg

doi:10.1038/s41467-018-05412-0

Nature Communications (Aug 2018)

Regulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling

Wenji Piao,
Yanbao Xiong,
Konrad Famulski,
C. Colin Brinkman,
Lushen Li,
Nicholas Toney,
Chelsea Wagner,
Vikas Saxena,
Thomas Simon,
Jonathan S. Bromberg

Affiliations

Wenji Piao: Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
Yanbao Xiong: Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
Konrad Famulski: Department of Laboratory Medicine and Pathology, University of Alberta
C. Colin Brinkman: Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
Lushen Li: Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
Nicholas Toney: Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
Chelsea Wagner: Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
Vikas Saxena: Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
Thomas Simon: Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
Jonathan S. Bromberg: Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine

DOI: https://doi.org/10.1038/s41467-018-05412-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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Lymphotoxin beta receptor (LTβR) signalling regulates leukocyte migration through the lymphatic endothelial layers. Here, the authors show that treatment of an LTβR-derived decoy peptide can target the non-classical NFκB pathway to inhibit T cell and dendritic cell migration and ameliorate contact hypersensitivity in mouse models.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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