Functional Genomic and Biochemical Analysis Reveals Pleiotropic Effect of Congo Red on Aspergillus fumigatus

Zhonghua Liu; Shriya Raj; Norman van Rhijn; Marcin Fraczek; Jean-Philippe Michel; Odile Sismeiro; Rachel Legendre; Hugo Varet; Thierry Fontaine; Michael Bromley; Jean-Paul Latgé

doi:10.1128/mBio.00863-21

mBio (Jun 2021)

Functional Genomic and Biochemical Analysis Reveals Pleiotropic Effect of Congo Red on Aspergillus fumigatus

Zhonghua Liu,
Shriya Raj,
Norman van Rhijn,
Marcin Fraczek,
Jean-Philippe Michel,
Odile Sismeiro,
Rachel Legendre,
Hugo Varet,
Thierry Fontaine,
Michael Bromley,
Jean-Paul Latgé

Affiliations

Zhonghua Liu: Unité des Aspergillus, Institut Pasteur, Paris, France
Shriya Raj: Unité des Aspergillus, Institut Pasteur, Paris, France
Norman van Rhijn: Manchester Fungal Infection Group, The University of Manchester, Manchester, United Kingdom
Marcin Fraczek: Manchester Fungal Infection Group, The University of Manchester, Manchester, United Kingdom
Jean-Philippe Michel: Institut Galien Paris Sud, UMR CNRS 8612, Châtenay-Malabry, France
Odile Sismeiro: Transcriptome and Epigenome Platform, Biomics, C2RT, Institut Pasteur, Paris, France
Rachel Legendre: Transcriptome and Epigenome Platform, Biomics, C2RT, Institut Pasteur, Paris, France
Hugo Varet: ORCiD; Transcriptome and Epigenome Platform, Biomics, C2RT, Institut Pasteur, Paris, France
Thierry Fontaine: Unité des Aspergillus, Institut Pasteur, Paris, France
Michael Bromley: Manchester Fungal Infection Group, The University of Manchester, Manchester, United Kingdom
Jean-Paul Latgé: Unité des Aspergillus, Institut Pasteur, Paris, France

DOI: https://doi.org/10.1128/mBio.00863-21
Journal volume & issue: Vol. 12, no. 3

Abstract

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The compound Congo red (CR) has been historically used for coloring treatment and histological examination as well to inhibit the growth of yeast and filamentous fungi. It has been thought that CR binds to β-1,3-glucans in the fungal cell wall, disrupting the organization of the cell wall structure.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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