LIPID PROFILE AND SERUM INSULIN LEVELS IN GESTATIONAL DIABETES

Abstract

Objectives: To evaluate the glucose intolerance, insulin, and lipid profile in women who developedgestational Diabetes, compared to healthy pregnancy. Design: Observational studyPatients and Methods: One hundred pregnant women, 50 healthy as control group and 50 already diagnosedgestational diabetic women as study group were selected. Plasma fasting (FBS) and post prandial glucose(RBS), serum insulin and serum lipid profile (total lipids, cholesterol, triglycerides, HDL-cholesterol andLDL- c h o le s te ro l) o f b o th w e re m o n ito re d . M e a n v a lu e s w e re com p a re d u s in g t-te s t. Results: Mean FBS [124.76±4.22 vs. 90.06±1.20 mg/dl], mean RBS [221.38±6.68 vs. 120.32±1.97 mg/dl],insulin [32.10±0.83 vs. 17.88±0.54 |!IU/ml], mean cholesterol [216.60±5.87 vs. 166.38±3.19 mg/dl], meantriglycerides [189.36±6.76 vs. 106.28±2.85 mg/dl], LDL-cholesterol [131.08±4.73 vs. 102.48±2.18 mg/dl]and total lipids [825.24±16.92 vs. 653.96±15.40 mg/dl] were higher in GDM groups as compared to normalcontrols (p<0.01). Mean HDL-cholesterol [41.24±0.65 vs. 48.34±0.66 mg/dl] showed significantly lowerconcentration in GDM group as compared to controls (p<0.01). Conclusion: Mean insulin and lipid levels, except HDL-cholesterol, were significantly higher in gestationaldiabetics compared to controls.

Keywords

• gestational diabetes
• hyperlipidemia
• insulin resistance
• hypertriglyceridemia
• low density lipoproteins.
• high density lipoproteins