Nature Communications (May 2019)
Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis
- John A. Lees,
- Bart Ferwerda,
- Philip H. C. Kremer,
- Nicole E. Wheeler,
- Mercedes Valls Serón,
- Nicholas J. Croucher,
- Rebecca A. Gladstone,
- Hester J. Bootsma,
- Nynke Y. Rots,
- Alienke J. Wijmega-Monsuur,
- Elisabeth A. M. Sanders,
- Krzysztof Trzciński,
- Anne L. Wyllie,
- Aeilko H. Zwinderman,
- Leonard H. van den Berg,
- Wouter van Rheenen,
- Jan H. Veldink,
- Zitta B. Harboe,
- Lene F. Lundbo,
- Lisette C. P. G. M. de Groot,
- Natasja M. van Schoor,
- Nathalie van der Velde,
- Lars H. Ängquist,
- Thorkild I. A. Sørensen,
- Ellen A. Nohr,
- Alexander J. Mentzer,
- Tara C. Mills,
- Julian C. Knight,
- Mignon du Plessis,
- Susan Nzenze,
- Jeffrey N. Weiser,
- Julian Parkhill,
- Shabir Madhi,
- Thomas Benfield,
- Anne von Gottberg,
- Arie van der Ende,
- Matthijs C. Brouwer,
- Jeffrey C. Barrett,
- Stephen D. Bentley,
- Diederik van de Beek
Affiliations
- John A. Lees
- Department of Microbiology, New York University School of Medicine
- Bart Ferwerda
- Amsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam Neuroscience
- Philip H. C. Kremer
- Amsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam Neuroscience
- Nicole E. Wheeler
- Parasites and Microbes, Wellcome Sanger Institute
- Mercedes Valls Serón
- Amsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam Neuroscience
- Nicholas J. Croucher
- MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London
- Rebecca A. Gladstone
- Parasites and Microbes, Wellcome Sanger Institute
- Hester J. Bootsma
- Centre for Infectious Disease Control, National Institute for Public Health and the Environment
- Nynke Y. Rots
- Centre for Infectious Disease Control, National Institute for Public Health and the Environment
- Alienke J. Wijmega-Monsuur
- Centre for Infectious Disease Control, National Institute for Public Health and the Environment
- Elisabeth A. M. Sanders
- Centre for Infectious Disease Control, National Institute for Public Health and the Environment
- Krzysztof Trzciński
- Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children’s Hospital, University Medical Centre Utrecht
- Anne L. Wyllie
- Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children’s Hospital, University Medical Centre Utrecht
- Aeilko H. Zwinderman
- Amsterdam UMC, University of Amsterdam, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam Public Health
- Leonard H. van den Berg
- Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht
- Wouter van Rheenen
- Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht
- Jan H. Veldink
- Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht
- Zitta B. Harboe
- Department of Microbiological Surveillance and Research, Statens Serum Institut
- Lene F. Lundbo
- Department of Infectious Diseases, Hvidovre Hospital, University of Copenhagen
- Lisette C. P. G. M. de Groot
- Department of Human Nutrition, Wageningen University
- Natasja M. van Schoor
- Amsterdam UMC, VU University, Department of Epidemiology and Biostatistics, Amsterdam Public Health
- Nathalie van der Velde
- Amsterdam UMC, University of Amsterdam, Department of Internal Medicine, Geriatrics, Amsterdam Public Health
- Lars H. Ängquist
- Center for Clinical Research and Disease Prevention, Bispebjerg and Frederiksberg Hospitals, The Capital Region
- Thorkild I. A. Sørensen
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics
- Ellen A. Nohr
- Institute of Clinical Research, University of Southern Denmark
- Alexander J. Mentzer
- Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford
- Tara C. Mills
- Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford
- Julian C. Knight
- Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford
- Mignon du Plessis
- School of Pathology, Faculty of Health Sciences, University of Witwatersrand
- Susan Nzenze
- School of Pathology, Faculty of Health Sciences, University of Witwatersrand
- Jeffrey N. Weiser
- Department of Microbiology, New York University School of Medicine
- Julian Parkhill
- Parasites and Microbes, Wellcome Sanger Institute
- Shabir Madhi
- National Institute for Communicable Diseases
- Thomas Benfield
- Department of Infectious Diseases, Hvidovre Hospital, University of Copenhagen
- Anne von Gottberg
- School of Pathology, Faculty of Health Sciences, University of Witwatersrand
- Arie van der Ende
- Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology, Amsterdam Infection and Immunity
- Matthijs C. Brouwer
- Amsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam Neuroscience
- Jeffrey C. Barrett
- Parasites and Microbes, Wellcome Sanger Institute
- Stephen D. Bentley
- Parasites and Microbes, Wellcome Sanger Institute
- Diederik van de Beek
- Amsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam Neuroscience
- DOI
- https://doi.org/10.1038/s41467-019-09976-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Streptococcus pneumoniae is a causative agent of meningitis and bacteremia. In a combined pathogen and host GWAS, Lees et al. find that host genetic variation is associated with both susceptibility and severity of pneumococcal meningitis, and specific bacterial genetic variation associated with susceptibility.
