Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25

Brandon McLeod; Kazutoyo Miura; Stephen W. Scally; Alexandre Bosch; Ngan Nguyen; Hanjun Shin; Dongkyoon Kim; Wayne Volkmuth; Sebastian Rämisch; Jessica A. Chichester; Stephen Streatfield; Colleen Woods; William R. Schief; Daniel Emerling; C. Richter King; Jean-Philippe Julien

doi:10.1038/s41467-019-11980-6

Nature Communications (Sep 2019)

Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25

Brandon McLeod,
Kazutoyo Miura,
Stephen W. Scally,
Alexandre Bosch,
Ngan Nguyen,
Hanjun Shin,
Dongkyoon Kim,
Wayne Volkmuth,
Sebastian Rämisch,
Jessica A. Chichester,
Stephen Streatfield,
Colleen Woods,
William R. Schief,
Daniel Emerling,
C. Richter King,
Jean-Philippe Julien

Affiliations

Brandon McLeod: Program in Molecular Medicine, The Hospital for Sick Children Research Institute
Kazutoyo Miura: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Stephen W. Scally: Program in Molecular Medicine, The Hospital for Sick Children Research Institute
Alexandre Bosch: Program in Molecular Medicine, The Hospital for Sick Children Research Institute
Ngan Nguyen: Atreca
Hanjun Shin: Atreca
Dongkyoon Kim: Atreca
Wayne Volkmuth: Atreca
Sebastian Rämisch: Department of Immunology and Microbial Science, The Scripps Research Institute
Jessica A. Chichester: Gene Therapy Program & Orphan Disease Center, Perelman School of Medicine, The University of Pennsylvania
Stephen Streatfield: Fraunhofer USA Center for Molecular Biotechnology CMB
Colleen Woods: PATH’s Malaria Vaccine Initiative
William R. Schief: Department of Immunology and Microbial Science, The Scripps Research Institute
Daniel Emerling: Atreca
C. Richter King: PATH’s Malaria Vaccine Initiative
Jean-Philippe Julien: Program in Molecular Medicine, The Hospital for Sick Children Research Institute

DOI: https://doi.org/10.1038/s41467-019-11980-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

Read online

Pfs25 is a transmission-blocking vaccine candidate for Plasmodium. Here, McLeod et al. analyze the antibody response to Pfs25 in sera from a clinical trial evaluating a Pfs25 vaccine candidate, identify a potent transmission-blocking antibody and determine recognized epitopes on Pfs25.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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