Artery Research (Dec 2009)

P8.10 THE RELATIONSHIP BETWEEN AUGMENTATION INDEX AND AGEING: A META-REGRESSION ANALYSIS

  • A.J. Baksi,
  • T.A. Treibel,
  • J.E. Davies,
  • N. Hadjiloizou,
  • R.A. Foale,
  • K.H. Parker,
  • D.P. Francis,
  • J. Mayet,
  • A.D. Hughes

DOI
https://doi.org/10.1016/j.artres.2009.10.116
Journal volume & issue
Vol. 3, no. 4

Abstract

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It has been reported that augmentation index (AIx) increases with age, but that the increase is more prominent in younger subjects [1], and may even decrease with age in individuals over 50yrs [2]. We undertook a meta-analysis of the published literature of 9,551 individuals (5,659 male), aged 4 to 91 years (mean 54.2 years) and undertook meta-regression to further investigate the relationship of AIx with age. AIx increased with age (0.51 (0.41, 0.61) %/yr; coefficient (95% CI); adjusted r2=59.97%; p<0.0001) with little evidence of marked non-linearity over the life course (Figure). Meta-analysis of AIx vs age (solid line) with LOWESS fit shown(dashed line). This meta-analysis suggests that AIx increases relatively uniformly with age, although there may be a small decline in the rate of increase at older ages.